Phenotypes associated with this allele

• Allele Symbol: Dock10^tm1Thar
• Allele Name: targeted mutation 1, Takayuki Harada
• Allele ID: MGI:7330190
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dock10^tm1Thar/Dock10^tm1Thar	involves: C57BL/6	MGI:7330193

Genotype
MGI:7330193

hm1

• Allelic Composition: Dock10^tm1Thar/Dock10^tm1Thar
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:300632 )

N • mice show no impairment on the rotarod test

cellular

abnormal microglial cell chemotaxis ( J:300632 )

• microglial migration toward ATP is reduced in the Boyden chamber

impaired macrophage chemotaxis ( J:300632 )

• CCL2-induced macrophage migration activity is reduced in the Boyden chamber, indicating reduced chemotactic response of macrophages

hematopoietic system

abnormal microglial cell chemotaxis ( J:300632 )

• microglial migration toward ATP is reduced in the Boyden chamber

impaired macrophage chemotaxis ( J:300632 )

• CCL2-induced macrophage migration activity is reduced in the Boyden chamber, indicating reduced chemotactic response of macrophages

decreased B cell number ( J:300632 )

• mild reduction in the population of B220+ B cells

• however, splenocytes show no differences in the population of CD3+CD4+ T cells, CDkk3+CD8+T cells, and CD11C+ dendritic cells or in T cell proliferation in vitro

immune system

abnormal microglial cell chemotaxis ( J:300632 )

• microglial migration toward ATP is reduced in the Boyden chamber

impaired macrophage chemotaxis ( J:300632 )

• CCL2-induced macrophage migration activity is reduced in the Boyden chamber, indicating reduced chemotactic response of macrophages

decreased B cell number ( J:300632 )

• mild reduction in the population of B220+ B cells

• however, splenocytes show no differences in the population of CD3+CD4+ T cells, CDkk3+CD8+T cells, and CD11C+ dendritic cells or in T cell proliferation in vitro

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:300632 )

♀ • mice exhibit reduced severity of myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE), showing reduced infiltrating cells and demyelination in the spinal cord and a trend toward reduced infiltrating cells and demyelination in the optic nerves, no weight loss, and lower number of CD3+ cells, B220+ cells, iba1+ cells, and GFAP+ cells in the spinal cord by day 30

nervous system

nervous system phenotype ( J:300632 )

N • retinal ganglion cells, Muller glial cells, and optic nerves, and astrocytes, microglia, neurons and myelin in the spinal cord are normal at P10 indicating that development of neural cells and myelin is not affected

abnormal microglial cell chemotaxis ( J:300632 )

• microglial migration toward ATP is reduced in the Boyden chamber

abnormal astrocyte physiology ( J:300632 )

• CCL2 production by astrocytes stimulated with LPS or CpG is reduced indicating that astrocyte activity is impaired

vision/eye

vision/eye phenotype ( J:300632 )

N • mice show no impairment in visual function on the multifocal electroretinogram