Phenotypes associated with this allele

• Allele Symbol: Dock11^tm1Thar
• Allele Name: targeted mutation 1, Takayuki Harada
• Allele ID: MGI:7330191
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dock11^tm1Thar/Dock11^tm1Thar	involves: C57BL/6	MGI:7331657

Genotype
MGI:7331657

hm1

• Allelic Composition: Dock11^tm1Thar/Dock11^tm1Thar
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:300632 )

♀N • splenocytes show no differences in the population of CD3+CD4+ T cells, CDkk3+CD8+T cells, and CD11C+ dendritic cells or in T cell proliferation in vitro

♀N • mice show comparable severity of myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) to wild-type mice

impaired macrophage chemotaxis ( J:300632 )

♀ • CCL2-induced macrophage migration activity is reduced in the Boyden chamber, indicating reduced chemotactic response of macrophages

hematopoietic system

impaired macrophage chemotaxis ( J:300632 )

♀ • CCL2-induced macrophage migration activity is reduced in the Boyden chamber, indicating reduced chemotactic response of macrophages

cellular

impaired macrophage chemotaxis ( J:300632 )

♀ • CCL2-induced macrophage migration activity is reduced in the Boyden chamber, indicating reduced chemotactic response of macrophages

behavior/neurological

behavior/neurological phenotype ( J:300632 )

♀N • mice show no impairment on the rotarod test

nervous system

nervous system phenotype ( J:300632 )

♀N • retinal ganglion cells, Muller glial cells, and optic nerves, and astrocytes, microglia, neurons and myelin in the spinal cord are normal at P10 indicating that development of neural cells and myelin is not affected

vision/eye

vision/eye phenotype ( J:300632 )

♀N • mice show no impairment in visual function on the multifocal electroretinogram