Phenotypes associated with this allele

• Allele Symbol: Cmtm5^{tm1d(KOMP)Wtsi}
• Allele Name: targeted mutation 1d, Wellcome Trust Sanger Institute
• Allele ID: MGI:7330369
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cmtm5^tm1d(KOMP)Wtsi/Cmtm5^tm1d(KOMP)Wtsi	B6(Cg)-Cmtm5^tm1d(KOMP)Wtsi	MGI:7331500
cx2	Cmtm5^tm1d(KOMP)Wtsi/Cmtm5^tm1d(KOMP)Wtsi Wld^s/+	B6(Cg)-Wld^s Cmtm5^tm1d(KOMP)Wtsi	MGI:7331615

Genotype
MGI:7331500

hm1

• Allelic Composition: Cmtm5^{tm1d(KOMP)Wtsi}/Cmtm5^{tm1d(KOMP)Wtsi}
• Genetic Background: B6(Cg)-Cmtm5^{tm1d(KOMP)Wtsi}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal axon morphology ( J:327261 )

• progressive increase in the number of axonal pathological profiles in optic nerves indicating axonopathy

• however, axonal diameters in the optic nerves are normal

Genotype
MGI:7331615

cx2

• Allelic Composition: Cmtm5^{tm1d(KOMP)Wtsi}/Cmtm5^{tm1d(KOMP)Wtsi}; Wld^s/+
• Genetic Background: B6(Cg)-Wld^s Cmtm5^{tm1d(KOMP)Wtsi}

nervous system

abnormal axon morphology ( J:327261 )

• mice show reduced number of pathologically appearing axons in optic nerves at 6 months of age compared to homozygous Cmtm5^{tm1d(KOMP)Wtsi} mice but still increased number compared to wild-type mice