Phenotypes associated with this allele

• Allele Symbol: Abca13^em1Kueda
• Allele Name: endonuclease-mediated mutation 1, Kazumitsu Ueda
• Allele ID: MGI:7330391
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Abca13^em1Kueda/Abca13^em1Kueda	C57BL/6N-Abca13^em1Kueda/Kueda	MGI:7330393

Genotype
MGI:7330393

hm1

• Allelic Composition: Abca13^em1Kueda/Abca13^em1Kueda
• Genetic Background: C57BL/6N-Abca13^em1Kueda/Kueda

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal synaptic vesicle endocytosis ( J:304162 )

• primary mouse cortical neurons at 14 days in vitro show impaired synaptic vesicle endocytosis

abnormal neuron physiology ( J:304162 )

• primary mouse cortical neurons at 14 days in vitro show decreased accumulation of vesicular cholesterol and impaired synaptic vesicle endocytosis

decreased prepulse inhibition ( J:304162 )

• mice show reduced levels of prepulse inhibition

• however, mice show no differences in the startle response

cellular

abnormal synaptic vesicle endocytosis ( J:304162 )

• primary mouse cortical neurons at 14 days in vitro show impaired synaptic vesicle endocytosis

behavior/neurological

behavior/neurological phenotype ( J:304162 )

N • mice show no differences in behavior in the open field test, light and dark transition test, elevated plus maze, hot plate test, social interaction test, elevated plus maze test, hot pate test, social interaction test, forced swim test, rotarod test, startle response/prepulse inhibition test, Y-maze test, Barnes maze test, fear conditioning test, and tail suspension test