Phenotypes associated with this allele

• Allele Symbol: Lgi3^tm1.2Mejr
• Allele Name: targeted mutation 1.2, Dies Meijer
• Allele ID: MGI:7331636
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lgi3^tm1.2Mejr/Lgi3^tm1.2Mejr	involves: C57BL/6J	MGI:7331641
hm2	Lgi3^tm1.2Mejr/Lgi3^tm1.2Mejr	Not Specified	MGI:7444415
cx3	Lgi2^tm1.2Mejr/Lgi2^tm1.2Mejr Lgi3^tm1.2Mejr/Lgi3^tm1.2Mejr	Not Specified	MGI:7444417

Genotype
MGI:7331641

hm1

• Allelic Composition: Lgi3^tm1.2Mejr/Lgi3^tm1.2Mejr
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal juxtaparanode morphology ( J:327404 )

• mice show reduced and mis-localized Kv1 channel complexes in myelinated peripheral axons at the juxtaparanodal domain of the node of Ranvier and this mis-localization of Kv1 channel complexes is further exacerbated following nerve injury

mortality/aging

mortality/aging ( J:327404 )

N • mice have a normal life span

behavior/neurological

behavior/neurological phenotype ( J:327404 )

N • mice exhibit no overt abnormal behavior

reproductive system

reproductive system phenotype ( J:327404 )

N • mice are fertile

Genotype
MGI:7444415

hm2

• Allelic Composition: Lgi3^tm1.2Mejr/Lgi3^tm1.2Mejr
• Genetic Background: Not Specified

nervous system

abnormal neuron morphology ( J:333962 )

• mislocalized Kv1 channels at the juxtaparanodal membrane in neurons

Genotype
MGI:7444417

cx3

• Allelic Composition: Lgi2^tm1.2Mejr/Lgi2^tm1.2Mejr; Lgi3^tm1.2Mejr/Lgi3^tm1.2Mejr
• Genetic Background: Not Specified

mortality/aging

postnatal lethality, complete penetrance ( J:333962 )

• mice die around P12

nervous system

abnormal neuron morphology ( J:333962 )

• absent Kv1 channels complex accumulation at the juxtaparanodal membrane in neurons

growth/size/body

postnatal growth retardation ( J:333962 )

behavior/neurological

tremors ( J:333962 )

• from the second postnatal week