Phenotypes associated with this allele

• Allele Symbol: Odf4^em1Ktos
• Allele Name: endonuclease-mediated mutation 1, Kiyotaka Toshimori
• Allele ID: MGI:7331638
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Odf4^em1Ktos/Odf4^em1Ktos	involves: C57BL/6J * DBA/2J	MGI:7438097

Genotype
MGI:7438097

hm1

• Allelic Composition: Odf4^em1Ktos/Odf4^em1Ktos
• Genetic Background: involves: C57BL/6J * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal sperm flagellum morphology ( J:333391 )

♂ • residual cytoplasmic droplets

hairpin sperm flagellum ( J:333391 )

♂

oligozoospermia ( J:333391 )

♂ • reduced sperm in the cauda epididymis

asthenozoospermia ( J:333391 )

♂ • with immotile midpieces

decreased testis weight ( J:333391 )

♂

abnormal sperm capacitation ( J:333391 )

♂ • reduced ATP and ADP concentrations before and after capacitation

reduced male fertility ( J:333391 )

♂ • almost completely infertile

♂ • however, transgene expression of the gene restores fertility

endocrine/exocrine glands

decreased testis weight ( J:333391 )

♂

cellular

abnormal sperm flagellum morphology ( J:333391 )

♂ • residual cytoplasmic droplets

hairpin sperm flagellum ( J:333391 )

♂

oligozoospermia ( J:333391 )

♂ • reduced sperm in the cauda epididymis

asthenozoospermia ( J:333391 )

♂ • with immotile midpieces