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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Clk4em1Yihc
endonuclease-mediated mutation 1, Yi-Han Chen
MGI:7333070
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Clk4em1Yihc/Clk4em1Yihc
B6(FVB)-Clk4em1Yihc A1cfTg(Myh6-cre/Esr1*)1Jmk MGI:7333095


Genotype
MGI:7333095
cn1
Allelic
Composition
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Clk4em1Yihc/Clk4em1Yihc
Genetic
Background
B6(FVB)-Clk4em1Yihc A1cfTg(Myh6-cre/Esr1*)1Jmk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A1cfTg(Myh6-cre/Esr1*)1Jmk mutation (5 available); any A1cf mutation (39 available)
Clk4em1Yihc mutation (0 available); any Clk4 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• increased cross-sectional area without change in length in tamoxifen-treated mice
• in tamoxifen-treated mice
• however, overexpression of a phosphorylation-mimic mutant of NEXN (S437E) rescues cardiac hypertrophy
• in tamoxifen-treated mice
• in tamoxifen-treated mice
• in tamoxifen-treated mice
• however, overexpression of a phosphorylation-mimic mutant of NEXN (S437E) rescues fibrosis
• rapid onset in tamoxifen-treated mice with decreased left ventricular internal diameter, diastole, and a significant decrease in the left ventricular ejection fraction

growth/size/body
• in tamoxifen-treated mice
• however, overexpression of a phosphorylation-mimic mutant of NEXN (S437E) rescues cardiac hypertrophy
• in tamoxifen-treated mice
• in tamoxifen-treated mice

muscle
• increased cross-sectional area without change in length in tamoxifen-treated mice
• in tamoxifen-treated mice
• however, overexpression of a phosphorylation-mimic mutant of NEXN (S437E) rescues cardiac hypertrophy
• disrupted integrity ruptured myofilaments, blurred Z-disk, and mitochondrial abnormalities in cardiomyocytes of tamoxifen-treated mice
• in cardiomyocytes of tamoxifen-treated mice

respiratory system
• in tamoxifen-treated mice

cellular
• in tamoxifen-treated mice
• however, overexpression of a phosphorylation-mimic mutant of NEXN (S437E) rescues fibrosis





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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory