All Phenotypes Vmn2r53<em1Ktou> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Vmn2r53^em1Ktou
endonuclease-mediated mutation 1, Kazushige Touhara
MGI:7334897

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vmn2r53^em1Ktou/Vmn2r53^em1Ktou	BALB/cCrSlc-Vmn2r53^em1Ktou	MGI:7335005
cx2	Vmn2r53^em1Ktou/Vmn2r53^em1Ktou Pgr^{tm1.1(cre)Shah}/Pgr⁺	involves: 129S/SvEv * BALB/cCrSlc * C57BL/6J	MGI:7335007
cx3	Vmn2r53^em1Ktou/Vmn2r53⁺ Pgr^{tm1.1(cre)Shah}/Pgr⁺	involves: 129S/SvEv * BALB/cCrSlc * C57BL/6J	MGI:7335008

Allelic Composition	Vmn2r53^em1Ktou/Vmn2r53^em1Ktou
Genetic Background	BALB/cCrSlc-Vmn2r53^em1Ktou

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vmn2r53^em1Ktou mutation (0 available); any Vmn2r53 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal aggression towards conspecific ( J:327623 )

• with the second intruder in a resident-intruder assay, male mice fail to exhibit an increase in aggression toward castrated mice swabbed in intact male urine or a Vmn2r53-activating urine fraction unlike wild-type mice

• however, mice exhibit normal aggression toward the first intruder

decreased aggression towards male mice ( J:327623 )

• in a resident-intruder assay, male mice exhibit lower numbers of attacks and total duration of attacks compared with wild-type mice

• male mice attack less urine-swabbed castrated male intruders compared with wild-type mice

• however, mice exhibit normal percentage of attacking male mice and sex discrimination

Allelic Composition	Vmn2r53^em1Ktou/Vmn2r53^em1Ktou Pgr^{tm1.1(cre)Shah}/Pgr⁺
Genetic Background	involves: 129S/SvEv * BALB/cCrSlc * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgr^{tm1.1(cre)Shah} mutation (1 available); any Pgr mutation (75 available)
Vmn2r53^em1Ktou mutation (0 available); any Vmn2r53 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased aggression towards male mice ( J:327623 )

• mice injected with an adenovirus expressing a cre-dependent GCaMP6s exhibit no response to a first or second intruder swabbed with the Vmn2r53-activating urine fraction unlike wild-type mice

• however, mice exhibit a normal response to female and castrated male urine or mice, and injection of clozapine N-oxide (selective agonist of hM4D(Gi)) restores aggressiveness

Allelic Composition	Vmn2r53^em1Ktou/Vmn2r53⁺ Pgr^{tm1.1(cre)Shah}/Pgr⁺
Genetic Background	involves: 129S/SvEv * BALB/cCrSlc * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased aggression towards male mice ( J:327623 )

• mice injected with an adenovirus expressing a cre-dependent GCaMP6s exhibit no response to a second intruder swabbed with the Vmn2r53-activating urine fraction unlike wild-type mice

• however, mice exhibit a normal response to the first intruder, and injection of clozapine N-oxide (selective agonist of hM4D(Gi)) restores aggressiveness

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