Phenotypes associated with this allele

• Allele Symbol: Tmem174^tm1Myz
• Allele Name: targeted mutation 1, Makoto Miyazaki
• Allele ID: MGI:7336005
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tmem174^tm1Myz/Tmem174^tm1Myz	either: B6.Cg-Tmem174^tm1Myz or D2.Cg-Tmem174^tm1Myz	MGI:7336014

Genotype
MGI:7336014

hm1

• Allelic Composition: Tmem174^tm1Myz/Tmem174^tm1Myz
• Genetic Background: either: B6.Cg-Tmem174^tm1Myz or D2.Cg-Tmem174^tm1Myz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal circulating hormone level ( J:328157 )

• mice show drastically higher levels of FGF23 in the serum

increased circulating parathyroid hormone level ( J:328157 )

• mice show drastically higher levels of parathyroid hormone in the serum

• however, levels of 1,25(OH)2D (calcitriol) are not altered

increased circulating phosphate level ( J:328157 )

• mice exhibit 2-fold higher serum phosphate levels

• levels of serum phosphate are increased in mice fed both a low-phosphate and high-phosphate diet

• however, levels of serum creatinine, calcium, magnesium, sodium, potassium, and chloride are normal and renal morphology is normal

decreased urine phosphate level ( J:328157 )

• urinary phosphate, but not calcium, excretion is reduced

renal/urinary system

decreased urine phosphate level ( J:328157 )

• urinary phosphate, but not calcium, excretion is reduced

abnormal kidney physiology ( J:328157 )

• total phosphate uptake of renal brush border membrane is increased

• however, sodium-independent phosphate uptake is not changed

cardiovascular system

calcified artery ( J:328157 )

• mice develop severe vascular calcifications

growth/size/body

growth/size/body region phenotype ( J:328157 )

N • mice exhibit a normal growth rate