reproductive system
small testis
(
J:328215
)
• after 35 days of tamoxifen treatment
|
• after 35 days of tamoxifen treatment
|
• with partial collapse of seminiferous tubules and defective germ line maturation in tamoxifen-treated mice
|
• 4 of 7 tamoxifen-treated male mice are infertile compared with 1 of 5 wild-type mice
|
behavior/neurological
• on a rotarod at three months in tamoxifen-treated mice
|
endocrine/exocrine glands
small testis
(
J:328215
)
• after 35 days of tamoxifen treatment
|
• after 35 days of tamoxifen treatment
|
• with partial collapse of seminiferous tubules and defective germ line maturation in tamoxifen-treated mice
|
growth/size/body
• reduced weight gain for 70 days following tamoxifen treatment with mice never catching up to wild-type mice
|
• after 40-50 days of tamoxifen treatment
|
homeostasis/metabolism
• after 43 days of tamoxifen treatment
|
• in tamoxifen-treated mice
|
• in tamoxifen-treated mice
|
liver/biliary system
• after 40-50 days of tamoxifen treatment
|
• with ballooning degeneration in the parenchyma and occasional foci of lymphocytic infiltration in tamoxifen-treated mice
|
• enlarged in tamoxifen-treated mice
|
• in tamoxifen-treated mice
|
immune system
• with ballooning degeneration in the parenchyma and occasional foci of lymphocytic infiltration in tamoxifen-treated mice
|
nervous system
cellular
• in tamoxifen-treated mice
|