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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dido1tm3Cmar
targeted mutation 3, Carlos Martinez-A
MGI:7336082
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Dido1tm3Cmar/Dido1tm3.1Cmar
Ndor1Tg(UBC-cre/ERT2)1Ejb/Ndor1+ 		involves: 129S/SvEv * C57BL/6 MGI:7343747


Genotype
MGI:7343747
cn1
Allelic
Composition		 Dido1tm3Cmar/Dido1tm3.1Cmar
Ndor1Tg(UBC-cre/ERT2)1Ejb/Ndor1+
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dido1tm3.1Cmar mutation (0 available); any Dido1 mutation (186 available)
Dido1tm3Cmar mutation (1 available); any Dido1 mutation (186 available)
Ndor1Tg(UBC-cre/ERT2)1Ejb mutation (6 available); any Ndor1 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
small testis ( J:328215 )
• after 35 days of tamoxifen treatment
decreased testis weight ( J:328215 )
• after 35 days of tamoxifen treatment
testis degeneration ( J:328215 )
• with partial collapse of seminiferous tubules and defective germ line maturation in tamoxifen-treated mice
male infertility ( J:328215 )
• 4 of 7 tamoxifen-treated male mice are infertile compared with 1 of 5 wild-type mice

behavior/neurological
ataxia ( J:328215 )
• progressively increasing with age in tamoxifen-treated mice
impaired coordination ( J:328215 )
• on a rotarod at three months in tamoxifen-treated mice
seizures ( J:328215 )
• in some tamoxifen-treated mice

endocrine/exocrine glands
small testis ( J:328215 )
• after 35 days of tamoxifen treatment
decreased testis weight ( J:328215 )
• after 35 days of tamoxifen treatment
testis degeneration ( J:328215 )
• with partial collapse of seminiferous tubules and defective germ line maturation in tamoxifen-treated mice

growth/size/body
decreased body weight ( J:328215 )
• reduced weight gain for 70 days following tamoxifen treatment with mice never catching up to wild-type mice
enlarged liver ( J:328215 )
• after 40-50 days of tamoxifen treatment

homeostasis/metabolism
increased circulating cholesterol level ( J:328215 )
• after 43 days of tamoxifen treatment

liver/biliary system
enlarged liver ( J:328215 )
• after 40-50 days of tamoxifen treatment
liver inflammation ( J:328215 )
• with ballooning degeneration in the parenchyma and occasional foci of lymphocytic infiltration in tamoxifen-treated mice
abnormal hepatocyte morphology ( J:328215 )
• enlarged in tamoxifen-treated mice
increased hepatocyte karyomegaly ( J:328215 )
• in tamoxifen-treated mice

immune system
liver inflammation ( J:328215 )
• with ballooning degeneration in the parenchyma and occasional foci of lymphocytic infiltration in tamoxifen-treated mice

nervous system
seizures ( J:328215 )
• in some tamoxifen-treated mice

cellular
increased hepatocyte karyomegaly ( J:328215 )
• in tamoxifen-treated mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory