Analysis Tools
behavior/neurological
| N |
• no change in basal somatosensation and chemically induced (Capsaicin or mustard oil) acute nociception
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• decrease in pain related grooming following sciatic nerve injury in male mice but not female mutant mice compared to similarly treated wild-type mice
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• 7 days following unilateral sciatic nerve injury, tactile hypersensitivity is largely absent in male mice unlike in similarly treated wild-type mice
• at later time points behavior is similarly to wild-type controls
• no difference in tactile hypersensitivity response is seen in female mice
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nervous system
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• reduced cellular calcium response profiles in dorsal root ganglion cultures from mutant males in response to mustard oil
• application of exogenous TNF rescues the response profile
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homeostasis/metabolism
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• pronounced downregulation of pro- and anti-inflammatory cytokines in the dorsal root ganglion of male but not female mutant mice compared to wild-type controls
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cellular
| N |
• despite localization to the mitochondria, no defects in mitochondrial function are seen
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immune system
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• pronounced downregulation of pro- and anti-inflammatory cytokines in the dorsal root ganglion of male but not female mutant mice compared to wild-type controls
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