All Phenotypes Rr271<em1Mgn> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rr271^em1Mgn
endonuclease-mediated mutation 1, Mark A Magnuson
MGI:7339169

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rr271^em1Mgn/Rr271^em1Mgn	involves: CD-1	MGI:7339249
cn2	Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺ Rr271^em1Mgn/Rr271⁺ Sox17^{tm2(EGFP/cre)Mgn}/Sox17⁺	involves: 129S6/SvEvTac * C57BL/6NCrl * CD-1	MGI:7339251

Allelic Composition	Rr271^em1Mgn/Rr271^em1Mgn
Genetic Background	involves: CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr271^em1Mgn mutation (1 available); any Rr271 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryo phenotype ( J:328045 )

N	• normal neural tube closure and optic vesicle, otic vesicle, branchial arch, heart tube and limb bud formation at appropriate stages • normal axis rotation • vessels and blood islands in yolk sac and embryonic tissues though less developed

decreased embryo size ( J:328045 )

• growth retardation from E9.5

• degraded posterior body trunk at E9.5 and E10.5

disorganized embryonic tissue ( J:328045 )

• effusions and disorganized blood vessels near tail tip at E9.5 and E10.5

growth/size/body

decreased embryo size ( J:328045 )

• growth retardation from E9.5

• degraded posterior body trunk at E9.5 and E10.5

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:328045 )

• no mice born

• growth retardation from E9.5 with virtual absence of embryos at E12.5

Allelic Composition	Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺ Rr271^em1Mgn/Rr271⁺ Sox17^{tm2(EGFP/cre)Mgn}/Sox17⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NCrl * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze} mutation (5 available); any Gt(ROSA)26Sor mutation (993 available)
Rr271^em1Mgn mutation (1 available); any Rr271 mutation (0 available)
Sox17^{tm2(EGFP/cre)Mgn} mutation (1 available); any Sox17 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

truncated foregut ( J:328045 )

• absence of ventral pancreato-biliary bud

embryo

failure of initiation of embryo turning ( J:328045 )

decreased embryo size ( J:328045 )

• growth retardation from E9.5

• degraded posterior body trunk at E9.5

growth/size/body

decreased embryo size ( J:328045 )

• growth retardation from E9.5

• degraded posterior body trunk at E9.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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