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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rr271em1Mgn
endonuclease-mediated mutation 1, Mark A Magnuson
MGI:7339169
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Rr271em1Mgn/Rr271em1Mgn involves: CD-1 MGI:7339249
cn2
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Rr271em1Mgn/Rr271+
Sox17tm2(EGFP/cre)Mgn/Sox17+
involves: 129S6/SvEvTac * C57BL/6NCrl * CD-1 MGI:7339251


Genotype
MGI:7339249
hm1
Allelic
Composition
Rr271em1Mgn/Rr271em1Mgn
Genetic
Background
involves: CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr271em1Mgn mutation (1 available); any Rr271 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
N
• normal neural tube closure and optic vesicle, otic vesicle, branchial arch, heart tube and limb bud formation at appropriate stages
• normal axis rotation
• vessels and blood islands in yolk sac and embryonic tissues though less developed
• growth retardation from E9.5
• degraded posterior body trunk at E9.5 and E10.5
• effusions and disorganized blood vessels near tail tip at E9.5 and E10.5

growth/size/body
• growth retardation from E9.5
• degraded posterior body trunk at E9.5 and E10.5

mortality/aging
• no mice born
• growth retardation from E9.5 with virtual absence of embryos at E12.5




Genotype
MGI:7339251
cn2
Allelic
Composition
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Rr271em1Mgn/Rr271+
Sox17tm2(EGFP/cre)Mgn/Sox17+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6NCrl * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze mutation (5 available); any Gt(ROSA)26Sor mutation (968 available)
Rr271em1Mgn mutation (1 available); any Rr271 mutation (0 available)
Sox17tm2(EGFP/cre)Mgn mutation (1 available); any Sox17 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• absence of ventral pancreato-biliary bud

embryo
• growth retardation from E9.5
• degraded posterior body trunk at E9.5

growth/size/body
• growth retardation from E9.5
• degraded posterior body trunk at E9.5





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/05/2024
MGI 6.24
The Jackson Laboratory