Phenotypes associated with this allele

• Allele Symbol: Rr293^tm1.1Mekk
• Allele Name: targeted mutation 1.1, Marc Ekker
• Allele ID: MGI:7356588
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rr293^tm1.1Mekk/Rr293^tm1.1Mekk	involves: 129S/SvEv * C57BL/6N	MGI:7356616
cx2	Rr291^tm1.1Mekk/Rr291^tm1.1Mekk Rr293^tm1.1Mekk/Rr293^tm1.1Mekk	involves: 129S/SvEv * C57BL/6N	MGI:7356618
cx3	Rr291^tm2.1Mekk/Rr291^tm2.1Mekk Rr293^tm1.1Mekk/Rr293^tm1.1Mekk	Not Specified	MGI:7356619

Genotype
MGI:7356616

hm1

• Allelic Composition: Rr293^tm1.1Mekk/Rr293^tm1.1Mekk
• Genetic Background: involves: 129S/SvEv * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

embryo phenotype ( J:312374 )

• no obvious developmental phenotype

mortality/aging

mortality/aging ( J:312374 )

• viable

reproductive system

reproductive system phenotype ( J:312374 )

• fertile

Genotype
MGI:7356618

cx2

• Allelic Composition: Rr291^tm1.1Mekk/Rr291^tm1.1Mekk; Rr293^tm1.1Mekk/Rr293^tm1.1Mekk
• Genetic Background: involves: 129S/SvEv * C57BL/6N

behavior/neurological

behavior/neurological phenotype ( J:312374 )

N • normal behavior in beam brake, elevated plus maze and open field tests

impaired cued conditioning behavior ( J:312374 )

increased social investigation ( J:312374 )

• increased interaction with juvenile

Genotype
MGI:7356619

cx3

• Allelic Composition: Rr291^tm2.1Mekk/Rr291^tm2.1Mekk; Rr293^tm1.1Mekk/Rr293^tm1.1Mekk
• Genetic Background: Not Specified

behavior/neurological

behavior/neurological phenotype ( J:312374 )

N • normal behavior in beam brake, elevated plus maze and open field tests