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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Xpo4em1Gshan
endonuclease-mediated mutation 1, Ge Shan
MGI:7356624
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Xpo4em1Gshan/Xpo4em1Gshan involves: C57BL/6J MGI:7356657
ht2
 		Xpo4em1Gshan/Xpo4+ involves: C57BL/6J MGI:7356658


Genotype
MGI:7356657
hm1
Allelic
Composition		 Xpo4em1Gshan/Xpo4em1Gshan
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xpo4em1Gshan mutation (0 available); any Xpo4 mutation (85 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality prior to tooth bud stage ( J:330082 )
• early embryonic lethality, at least before E10.5




Genotype
MGI:7356658
ht2
Allelic
Composition		 Xpo4em1Gshan/Xpo4+
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xpo4em1Gshan mutation (0 available); any Xpo4 mutation (85 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal spatial reference memory ( J:330082 )
• young adult mice exhibit a longer latency to find the target hole in the training phases of day 2 in the Barnes Maze
abnormal spatial working memory ( J:330082 )
• young adult mice exhibit reduced spontaneous alternation in the Y-maze

reproductive system
oligozoospermia ( J:330082 )
• half of the epididymal lumens have decreased amount of sperm or are almost empty
teratozoospermia ( J:330082 )
• sperm exhibit abnormalities such as coiled/winding flagella, irregular shapes, and missing head
coiled sperm flagellum ( J:330082 )
• some sperm show coiled/winding flagella
absent sperm head ( J:330082 )
• some sperm exhibit missing heads
asthenozoospermia ( J:330082 )
• sperm are less motile
abnormal testis physiology ( J:330082 )
• dramatic increase in cell death in testes
• R-loop and DNA damage levels are much higher and the levels of ciR-loop are increased in the testes
male infertility ( J:330082 )
• about half of males are infertile

nervous system
abnormal hippocampus neuron morphology ( J:330082 )
• decrease in neuron numbers in the hippocampus
decreased neuron number ( J:330082 )
• decrease in neuron numbers in the hippocampus
abnormal hippocampus physiology ( J:330082 )
• increase in DNA damage in the hippocampus
• increase of circRNA:DNA formation (ciR-loop) levels in the hippocampus
• overall RNA:DNA (R-loop) levels are increased in the hippocampus

endocrine/exocrine glands
abnormal testis physiology ( J:330082 )
• dramatic increase in cell death in testes
• R-loop and DNA damage levels are much higher and the levels of ciR-loop are increased in the testes

cellular
oligozoospermia ( J:330082 )
• half of the epididymal lumens have decreased amount of sperm or are almost empty
teratozoospermia ( J:330082 )
• sperm exhibit abnormalities such as coiled/winding flagella, irregular shapes, and missing head
coiled sperm flagellum ( J:330082 )
• some sperm show coiled/winding flagella
absent sperm head ( J:330082 )
• some sperm exhibit missing heads
increased cell death ( J:330082 )
• dramatic increase in cell death in testes
asthenozoospermia ( J:330082 )
• sperm are less motile




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory