Phenotypes associated with this allele

• Allele Symbol: Gpn1^em1(IMPC)J
• Allele Name: endonuclease-mediated mutation 1, Jackson
• Allele ID: MGI:7356629
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gpn1^em1(IMPC)J/Gpn1^em1(IMPC)J	C57BL/6NJ-Gpn1^em1(IMPC)J/Mmjax	MGI:7551125
ht2	Gpn1^em1(IMPC)J/Gpn1^+	C57BL/6NJ-Gpn1^em1(IMPC)J/Mmjax	MGI:7629011

Genotype
MGI:7551125

hm1

• Allelic Composition: Gpn1^em1(IMPC)J/Gpn1^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Gpn1^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Gpn1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Gpn1^em1(IMPC)J/Gpn1^em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. Blastocysts fail to hatch from the zona pellucida and die after 3 days in culture.

embryo

failure of blastocyst to hatch from the zona pellucida ( J:279207 )

• in vitro, blastocysts fail to hatch from the zona pellucida and are dead after 3 days in culture

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality prior to organogenesis, complete penetrance ( J:279207 )

• blastocysts are present in expected Mendelian ratios at E3.5; no homozygous embryos are recovered at E7.5

Genotype
MGI:7629011

ht2

• Allelic Composition: Gpn1^em1(IMPC)J/Gpn1⁺
• Genetic Background: C57BL/6NJ-Gpn1^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Gpn1

hematopoietic system

decreased mean corpuscular volume ( J:211773 )

IMPC - JAX

homeostasis/metabolism

decreased circulating bilirubin level ( J:211773 )

♂

IMPC - JAX

increased circulating glucose level ( J:211773 )

♂

IMPC - JAX

decreased circulating aspartate transaminase level ( J:211773 )

IMPC - JAX