Phenotypes associated with this allele

• Allele Symbol: Rr295^em1Hzo
• Allele Name: endonuclease-mediated mutation 1, Huda Y Zoghbi
• Allele ID: MGI:7356640
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rr295^em1Hzo/Rr295^em1Hzo	involves: C57BL/6J	MGI:7356675

Genotype
MGI:7356675

hm1

• Allelic Composition: Rr295^em1Hzo/Rr295^em1Hzo
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:311942 )

N • normal behavior in rotarod test at ages 10 weeks and 10 months

N • normal motor coordination in foot slip test at age 26 weeks

N • normal behavior in fear conditioning test at age 30 weeks

decreased aggression towards mice ( J:311942 )

• decreased winning percentage in tube test at age 40 weeks

increased anxiety-related response ( J:311942 )

• less time spent and shorter distance traveled in and fewer entries into open arms in elevated plus maze test at age 24 weeks

• normal behavior in elevated plus maze at age 9 weeks

abnormal response to social novelty ( J:311942 )

• less time spent with novel mouse in three-chamber sociability test at age 24 weeks

hyperactivity ( J:311942 )

• increased horizontal activity counts in open field test at age 10 weeks

increased locomotor activity ( J:311942 )

• greater distance traveled in open field test at age 10 weeks

nervous system

nervous system phenotype ( J:311942 )

N • normal sensorimotor neuron gating in pre-pulse inhibition assay at age 24 weeks