All Phenotypes Lrrc46<em1Cya> MGI Mouse

immotile sperm ( J:330199 )

• no motile spermatozoa are seen in mice, with path velocity, progressive velocity, and track speed of spermatozoa reduced to 0

abnormal spermatogenesis ( J:330199 )

• sperm show abnormal head shaping development

• although no differences in sperm head shaping from the Golgi apparatus period to the capping period (step 1 to step 8) are seen, major morphological differences in sperm head are seen during acrosomal migration (steps 9-13) and the chromatin condensation period (steps 14-16)

• even though head shaping is initiated at step 9 and step 10 and elongated spermatid head morphology is fairly normal, during steps 11-18 of the spermatid head shaping period, sperm present abnormal, hook-shaped heads

• flagella is absent in developing spermatids in the seminiferous tubules

abnormal sperm flagellum morphology ( J:330199 )

• sperm exhibit multiple morphological abnormalities of the sperm flagella (MMAF) phenotypes, with higher percentage of short, coiled, irregular, or absent flagella

abnormal outer dense fiber morphology ( J:330199 )

• sperm flagellum shows disarrangement and hyperplasia of outer dense fibers

abnormal sperm axoneme morphology ( J:330199 )

• the central pair microtubule structure is absent or disrupted in the flagellum

• various peri-axonemal microtubule components are distorted and nine double microtubule doublets split with each other

absent sperm axonemal central pair ( J:330199 )

abnormal sperm mitochondrial sheath morphology ( J:330199 )

• sperm flagellum shows hypertrophy and hyperplasia of mitochondria

increased sperm mitochondrial size ( J:330199 )

absent sperm fibrous sheath ( J:330199 )

absent sperm flagellum ( J:330199 )

coiled sperm flagellum ( J:330199 )

short sperm flagellum ( J:330199 )

oligozoospermia ( J:330199 )

• only a few spermatozoa are detected in the epididymal lumen and some dead cells are seen in the seminiferous tubules

• sperm count is decreased in the caudal epididymis

abnormal sperm head morphology ( J:330199 )

• sperm exhibit a variety of abnormal head shapes

• abnormally elongated and constricted sperm head shapes in seminiferous tubules

• some mature spermatozoa with head defects are seen in the stage IX seminiferous tubules

detached acrosome ( J:330199 )

• detachment of the acrosome from the nuclear envelope from step 11 to step 16 in the flagella, indicating acrosomal defects

abnormal manchette morphology ( J:330199 )

• manchette formation is normal in step 8 spermatids, however step 9-13 spermatids have abnormally long and deformed manchettes, indicating abnormal spermatozoa manchette formation from step 8-13

elongated manchette ( J:330199 )

• spermatids have abnormally long manchettes at step 9-13 of sperm development

male infertility ( J:330199 )

• males mated with wild-type females produce no pups indicating male infertility

• however, males show no differences in testis size or weight and females exhibit normal fertility