All Phenotypes Kctd13<em1Djla> MGI Mouse

decreased male germ cell number ( J:330265 )

• testes show no overt defects in spermatogenesis at 2 months of age, however with age, missing generations of germ cells are seen

• the total number of PLZF-positive spermatogonia is decreased in seminiferous tubule cross-sections

oligozoospermia ( J:330265 )

• decrease in sperm concentration

asthenozoospermia ( J:330265 )

• decrease in sperm motility

decreased seminal vesicle weight ( J:330265 )

decreased Sertoli cell number ( J:330265 )

• the total number of Sertoli cells per seminiferous tubule cross-section is decreased in 2-month-old males

small testis ( J:330265 )

• testes are smaller, regardless of being cryptorchid

decreased testis weight ( J:330265 )

cryptorchism ( J:330265 )

• 57.14% of mice present with cryptorchidism

• 33.33% of mice have unilateral and 23.8% of mice have bilateral cryptorchidism

abnormal penis morphology ( J:330265 )

• male urogenital mating protuberance length is shorter

small penile bone ( J:330265 )

• the baculum length and base width are shorter and narrower, respectively

• however, the urethral meatus location is normal

small penis ( J:330265 )

• penis is smaller and males show reduced penile lengths, with 13 of 15 males having micropenises

decreased epididymis weight ( J:330265 )

reduced male fertility ( J:330265 )

• males are subfertile and produce lower number of litters in a 6-month period when mated with wild-type females, show greater average days between litters, and produce smaller cumulative number of pups

• however, no differences in serum testosterone, FSH, or LH levels are seen in males