Phenotypes associated with this allele

• Allele Symbol: Awat1^em1Akih
• Allele Name: endonuclease-mediated mutation 1, Akio Kihara
• Allele ID: MGI:7367579
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Awat1^em1Akih/Awat1^em1Akih	C57BL/6J-Awat1^em1Akih/Akih	MGI:7378174

Genotype
MGI:7378174

hm1

• Allelic Composition: Awat1^em1Akih/Awat1^em1Akih
• Genetic Background: C57BL/6J-Awat1^em1Akih/Akih

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal Meibomian gland morphology ( J:330312 )

• orifice of the meibomian gland clogged with semiliquid substance with a slightly higher lipid melting point than in wild-type mice

• however, acini of the meibomian glands and gland size are normal

abnormal tear film morphology ( J:330312 )

• reduced tear breakup time

dry eyes ( J:330312 )

• not as severe as in Awat2 null or double null mice

behavior/neurological

increased blinking frequency ( J:330312 )

integument

abnormal Meibomian gland morphology ( J:330312 )

• orifice of the meibomian gland clogged with semiliquid substance with a slightly higher lipid melting point than in wild-type mice

• however, acini of the meibomian glands and gland size are normal

abnormal Meibomian gland physiology ( J:330312 )

• reduced (O-acyl)-omega-hydroxy fatty acids in the meibum lipids

• modestly reduced total tri-unsaturated species of 1 omega wax diesters

endocrine/exocrine glands

abnormal Meibomian gland morphology ( J:330312 )

• orifice of the meibomian gland clogged with semiliquid substance with a slightly higher lipid melting point than in wild-type mice

• however, acini of the meibomian glands and gland size are normal

abnormal Meibomian gland physiology ( J:330312 )

• reduced (O-acyl)-omega-hydroxy fatty acids in the meibum lipids

• modestly reduced total tri-unsaturated species of 1 omega wax diesters