Phenotypes associated with this allele

• Allele Symbol: Awat2^em1Akih
• Allele Name: endonuclease-mediated mutation 1, Akio Kihara
• Allele ID: MGI:7367580
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Awat2^em1Akih/Awat2^em1Akih	C57BL/6J-Awat2^em1Akih/Akih	MGI:7378176

Genotype
MGI:7378176

hm1

• Allelic Composition: Awat2^em1Akih/Awat2^em1Akih
• Genetic Background: C57BL/6J-Awat2^em1Akih/Akih

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal Meibomian gland morphology ( J:330312 )

• orifice of the meibomian gland clogged with paste-like substance with a much higher lipid melting point than in wild-type mice

• however, acini of the meibomian glands are normal

enlarged Meibomian gland ( J:330312 )

abnormal cornea morphology ( J:330312 )

• corneal damage and irregularities from 11 weeks of age increasing until 23 weeks

abnormal tear film morphology ( J:330312 )

• reduced tear breakup time decreasing with age

excessive tearing ( J:330312 )

• with greater water evaporation from the ocular surface

dry eyes ( J:330312 )

• more severe than in Awat1 null mice

behavior/neurological

increased blinking frequency ( J:330312 )

integument

abnormal Meibomian gland morphology ( J:330312 )

• orifice of the meibomian gland clogged with paste-like substance with a much higher lipid melting point than in wild-type mice

• however, acini of the meibomian glands are normal

enlarged Meibomian gland ( J:330312 )

abnormal Meibomian gland physiology ( J:330312 )

• slightly reduced (O-acyl)-omega-hydroxy fatty acids in the meibum lipids

• reduced 2-omega-wax diesters in the meibum lipids

• reduced total di- and tri-unsaturated species of 1 omega wax diesters

• almost all species of wax (mono)esters are absent from the meibum lipids

endocrine/exocrine glands

abnormal Meibomian gland morphology ( J:330312 )

• orifice of the meibomian gland clogged with paste-like substance with a much higher lipid melting point than in wild-type mice

• however, acini of the meibomian glands are normal

enlarged Meibomian gland ( J:330312 )

abnormal Meibomian gland physiology ( J:330312 )

• slightly reduced (O-acyl)-omega-hydroxy fatty acids in the meibum lipids

• reduced 2-omega-wax diesters in the meibum lipids

• reduced total di- and tri-unsaturated species of 1 omega wax diesters

• almost all species of wax (mono)esters are absent from the meibum lipids