Phenotypes associated with this allele

• Allele Symbol: Awat2^em2Akih
• Allele Name: endonuclease-mediated mutation 2, Akio Kihara
• Allele ID: MGI:7377728
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Awat1^em2Akih/Awat1^em2Akih Awat2^em2Akih/Awat2^em2Akih	C57BL/6J-Awat1^em2Akih Awat2^em2Akih	MGI:7378178

Genotype
MGI:7378178

cx1

• Allelic Composition: Awat1^em2Akih/Awat1^em2Akih; Awat2^em2Akih/Awat2^em2Akih
• Genetic Background: C57BL/6J-Awat1^em2Akih Awat2^em2Akih

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal Meibomian gland morphology ( J:330312 )

• orifice of the meibomian gland clogged with paste-like substance than in wild-type mice

• however, acini of the meibomian glands are normal

enlarged Meibomian gland ( J:330312 )

excessive tearing ( J:330312 )

• with greater water evaporation from the ocular surface

dry eyes ( J:330312 )

• more severe than in Awat1 null mice

behavior/neurological

increased blinking frequency ( J:330312 )

integument

abnormal Meibomian gland morphology ( J:330312 )

• orifice of the meibomian gland clogged with paste-like substance than in wild-type mice

• however, acini of the meibomian glands are normal

enlarged Meibomian gland ( J:330312 )

abnormal Meibomian gland physiology ( J:330312 )

• almost all species of wax (mono)esters are absent from the meibum lipids

• slightly reduced (O-acyl)-omega-hydroxy fatty acids in the meibum lipids as in Awat1 null mice

• reduced 2-omega-wax diesters in the meibum lipids

• partially impaired cholesteryl-(O-acyl)-omega-hydroxy fatty acids production in meibum lipids

• almost no di- and tri-unsaturated species of 1 omega wax diesters

endocrine/exocrine glands

abnormal Meibomian gland morphology ( J:330312 )

• orifice of the meibomian gland clogged with paste-like substance than in wild-type mice

• however, acini of the meibomian glands are normal

enlarged Meibomian gland ( J:330312 )

abnormal Meibomian gland physiology ( J:330312 )

• almost all species of wax (mono)esters are absent from the meibum lipids

• slightly reduced (O-acyl)-omega-hydroxy fatty acids in the meibum lipids as in Awat1 null mice

• reduced 2-omega-wax diesters in the meibum lipids

• partially impaired cholesteryl-(O-acyl)-omega-hydroxy fatty acids production in meibum lipids

• almost no di- and tri-unsaturated species of 1 omega wax diesters