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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dancrem1.1Bcgen
endonuclease-mediated mutation 1.1, Biocytogen LLC
MGI:7380639
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Dancrem1.1Bcgen/Dancrem1.1Bcgen involves: C57BL/6 MGI:7380640


Genotype
MGI:7380640
hm1
Allelic
Composition
Dancrem1.1Bcgen/Dancrem1.1Bcgen
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dancrem1.1Bcgen mutation (0 available); any Dancr mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• in a DEN-CCl4-induced carcinogenesis model, mice show reduced hepatocellular carcinoma development, with a 44.4% of tumor formation rate at 25 weeks compared to 100% for wild-type mice and with a lower proportion of tumors at 21 weeks of age

homeostasis/metabolism
• in a DEN-CCl4-induced carcinogenesis model, mice show reduced hepatocellular carcinoma development, with a 44.4% of tumor formation rate at 25 weeks compared to 100% for wild-type mice and with a lower proportion of tumors at 21 weeks of age

liver/biliary system
• in a diethylnitrosamine-carbon tetrachloride (DEN-CCl4)-induced carcinogenesis model, mice show reduced hepatic fibrosis compared to wild-type mice





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory