neoplasm
• in a DEN-CCl4-induced carcinogenesis model, mice show reduced hepatocellular carcinoma development, with a 44.4% of tumor formation rate at 25 weeks compared to 100% for wild-type mice and with a lower proportion of tumors at 21 weeks of age
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homeostasis/metabolism
• in a DEN-CCl4-induced carcinogenesis model, mice show reduced hepatocellular carcinoma development, with a 44.4% of tumor formation rate at 25 weeks compared to 100% for wild-type mice and with a lower proportion of tumors at 21 weeks of age
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liver/biliary system
• in a diethylnitrosamine-carbon tetrachloride (DEN-CCl4)-induced carcinogenesis model, mice show reduced hepatic fibrosis compared to wild-type mice
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