Phenotypes associated with this allele

• Allele Symbol: 4930463O16Rik^em1Bmpe
• Allele Name: endonuclease-mediated mutation 1, Beatrice Mandon-Pepin
• Allele ID: MGI:7382753
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	4930463O16Rik^em1Bmpe/4930463O16Rik^em1Bmpe	C57BL/6N-4930463O16Rik^em1Bmpe	MGI:7382756

Genotype
MGI:7382756

hm1

• Allelic Composition: 4930463O16Rik^em1Bmpe/4930463O16Rik^em1Bmpe
• Genetic Background: C57BL/6N-4930463O16Rik^em1Bmpe

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:328509 )

N • mice exhibit normal fertility, with normal litter size

N • males exhibit no differences in testicular size, testis morphology and histology, and cauda and caput epididymis, and in the different stages of seminiferous tubules

abnormal sperm flagellum morphology ( J:328509 )

♂ • decrease in the percentage of spermatozoa with coiled tail

♂ • increase in the distal mid-piece reflect, a defect developing in the epididymis and indicative of a sperm tail abnormality

oligozoospermia ( J:328509 )

♂ • sperm concentrations from the epididymis are reduced by 57.2% compared to wild-type levels

abnormal sperm motility ( J:328509 )

♂ • sperm show a decrease in motile mean straight line velocity and motile mean average path velocity

increased sperm motility ( J:328509 )

♂ • percentage of motile spermatozoa, the motile mean expressed as beat cross frequency, and progressive spermatozoa are increased

increased sperm progressive motility ( J:328509 )

♂ • increase in the percentage of progressive spermatozoa

cellular

abnormal sperm flagellum morphology ( J:328509 )

♂ • decrease in the percentage of spermatozoa with coiled tail

♂ • increase in the distal mid-piece reflect, a defect developing in the epididymis and indicative of a sperm tail abnormality

oligozoospermia ( J:328509 )

♂ • sperm concentrations from the epididymis are reduced by 57.2% compared to wild-type levels

abnormal sperm motility ( J:328509 )

♂ • sperm show a decrease in motile mean straight line velocity and motile mean average path velocity

increased sperm motility ( J:328509 )

♂ • percentage of motile spermatozoa, the motile mean expressed as beat cross frequency, and progressive spermatozoa are increased

increased sperm progressive motility ( J:328509 )

♂ • increase in the percentage of progressive spermatozoa