cardiovascular system
• enlarged chambers
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• 2x increase in heart weight to body weight ratio
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growth/size/body
• enlarged chambers
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• 2x increase in heart weight to body weight ratio
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• abdominal effusion (fluid accumulation)
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homeostasis/metabolism
liver/biliary system
• necrosis
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mortality/aging
• 50% of mice die from heart failure between 3 weeks and 6 months
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respiratory system