Phenotypes associated with this allele

• Allele Symbol: Ark2n^em1Wehi
• Allele Name: endonuclease-mediated mutation 1, Walter and Eliza Hall Institute of Medical Research
• Allele ID: MGI:7384485
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ark2n^em1Wehi/Ark2n^em1Wehi	C57BL/6J-8030462N17Rik^em1Wehi	MGI:7384487

Genotype
MGI:7384487

hm1

• Allelic Composition: Ark2n^em1Wehi/Ark2n^em1Wehi
• Genetic Background: C57BL/6J-8030462N17Rik^em1Wehi

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased total body fat amount ( J:330717 )

• increase in adiposity

increased white adipose tissue mass ( J:330717 )

growth/size/body

decreased lean body mass ( J:330717 )

♂ • males, but not females, show a decrease in lean mass

behavior/neurological

impaired exercise endurance ( J:330717 )

• mice fatigue earlier and run 20% less distance when subjected to treadmill exercise to exhaustion

muscle

decreased skeletal muscle fiber size ( J:330717 )

• tibialis anterior muscles have a smaller distribution of fiber-cross-sectional area with no difference in the total number of fibers or fiber composition

abnormal muscle physiology ( J:330717 )

• isolated soleus muscles show reduced specific force production but no difference in ex vivo fatigue is seen

• however, single fiber segments isolated from soleus muscles composed of about 40% and 60% slow- and fast-twitch fibers, respectively, show no difference in maximum calcium-activated specific force or calcium sensitivity of the contractile apparatus

• the amount of calcium that can be loaded into and released from the sarcoplasmic reticulum (SR) is decreased in fast-twitch, but not slow-twitch, fibers

• passive calcium leak from the SR is increased in fast-twitch but not slow-twitch fibers

impaired skeletal muscle contractility ( J:330717 )

• isolated soleus muscles show reduced specific force production

cardiovascular system

abnormal heart morphology ( J:330717 )

♂ • males, but not females, show a decrease in heart mass

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:330717 )

N • mice show no difference in carbohydrate or fat oxidation as assessed by the respiratory exchange ratio, no difference in food intake, in energy expenditure, whole-body glucose tolerance, or skeletal muscle insulin sensitivity

impaired exercise endurance ( J:330717 )

• mice fatigue earlier and run 20% less distance when subjected to treadmill exercise to exhaustion