Phenotypes associated with this allele

• Allele Symbol: Ncapd2^em1Cya
• Allele Name: endonuclease-mediated mutation 1, Cyagen Biosciences
• Allele ID: MGI:7384854
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Ncapd2^em1Cya/Ncapd2^+	C57BL/6N-Ncapd2^em1Cya	MGI:7384856

Genotype
MGI:7384856

ht1

• Allelic Composition: Ncapd2^em1Cya/Ncapd2⁺
• Genetic Background: C57BL/6N-Ncapd2^em1Cya

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased incidence of tumors by chemical induction ( J:310248 )

• mice show impaired development of AOM/DSS-induced colorectal cancer, showing less body weight loss during DSS treatment, longer colorectum length, reduced number of colorectal tumors with most located at the distal region, reduced number of different tumor sizes, reduced destruction of the epithelial architecture, and a decrease in the proliferation rates of colorectal tumors

digestive/alimentary system

decreased susceptibility to induced colitis ( J:310248 )

• mice are less susceptible to DSS-induced colitis, showing longer colorectum length than wild-type mice

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:310248 )

• mice show impaired development of AOM/DSS-induced colorectal cancer, showing less body weight loss during DSS treatment, longer colorectum length, reduced number of colorectal tumors with most located at the distal region, reduced number of different tumor sizes, reduced destruction of the epithelial architecture, and a decrease in the proliferation rates of colorectal tumors

immune system

decreased susceptibility to induced colitis ( J:310248 )

• mice are less susceptible to DSS-induced colitis, showing longer colorectum length than wild-type mice