Phenotypes associated with this allele

• Allele Symbol: Rps9^tm1.1Geno
• Allele Name: targeted mutation 1.1, Genoway
• Allele ID: MGI:7384901
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rps9^tm1.1Geno/Rps9^tm1.1Geno	involves: C57BL/6	MGI:7384952

Genotype
MGI:7384952

hm1

• Allelic Composition: Rps9^tm1.1Geno/Rps9^tm1.1Geno
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:329922 )

• in many mice starting at 6.5 months with a marked acceleration at 16 months of age

premature aging ( J:329922 )

• hair loss, graying, kyphosis, chest deformation, hunchback postures, eye cataracts, and poor body condition beginning at 9 months

growth/size/body

decreased body fat mass ( J:329922 )

• beginning at 6 to 9 months

decreased lean body mass ( J:329922 )

homeostasis/metabolism

abnormal lipid oxidation ( J:329922 )

• increased lipid peroxidation in 18-month-old female mice more so than in aged wild-type mice

immune system

increased monocyte cell number ( J:329922 )

• in female mice

decreased leukocyte cell number ( J:329922 )

• in female mice

adipose tissue

decreased subcutaneous adipose tissue amount ( J:329922 )

• at 18 months

decreased body fat mass ( J:329922 )

• beginning at 6 to 9 months

decreased interscapular fat pad weight ( J:329922 )

• at 18 months

behavior/neurological

behavior/neurological phenotype ( J:329922 )

N • mice exhibit normal performance on a rotarod

impaired swimming ( J:329922 )

• reduced swim speed

weakness ( J:329922 )

hypoactivity ( J:329922 )

• shortened walking bouts in a large open-field area

hematopoietic system

extramedullary hematopoiesis ( J:329922 )

• in the spleen of female mice

anemia ( J:329922 )

• mild in female mice

increased monocyte cell number ( J:329922 )

• in female mice

decreased leukocyte cell number ( J:329922 )

• in female mice

integument

decreased subcutaneous adipose tissue amount ( J:329922 )

• at 18 months

alopecia ( J:329922 )

• beginning at 9 months

cellular

abnormal lipid oxidation ( J:329922 )

• increased lipid peroxidation in 18-month-old female mice more so than in aged wild-type mice

oxidative stress ( J:329922 )

• in the mitochondria of 12-month-old female mice

renal/urinary system

ureter obstruction ( J:329922 )

• in 8 of 10 mice at 18 months

skeleton

kyphosis ( J:329922 )

• beginning at 9 months

vision/eye

cataract ( J:329922 )

• beginning at 9 months