Analysis Tools
mortality/aging
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• mice die after birth
• however, mice are present in normal Mendelian ratios at E18.5
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skeleton
|
• mildly decreased ossification in the radius
|
|
• fragments of cartilage unattached to either the spine or sternum instead of a closed rib cage
|
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• at E14.5 with lack of well-defined posterior vertebral elements
|
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• fragments of cartilage unattached to either the spine or sternum instead of a closed rib cage
|
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• little separation of vertebral segments and almost no ossification, particularly at the posterior end
|
embryo
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• absent tissue posterior to the hindlimbs
|
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• beginning at E9.5
|
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• irregularly spaced somites with indistinct boundaries, particularly at the posterior end of the embryo
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respiratory system
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• less polarized basal feet orientation
|
nervous system
homeostasis/metabolism
limbs/digits/tail
oligodactyly
(
J:328993
)
|
• complete penetrant loss of the posterior digit in all four limbs
|
|
• mildly decreased ossification in the radius
|
cellular
|
• less polarized basal feet orientation
|
cardiovascular system
|
• ectopic blood vessels
|
