Phenotypes associated with this allele

• Allele Symbol: Jmjd8^em1Kaso
• Allele Name: endonuclease-mediated mutation 1, Sona Kang
• Allele ID: MGI:7386879
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Jmjd8^em1Kaso/Jmjd8^em1Kaso	C57BL/6-Jmjd8^em1Kaso	MGI:7386883

Genotype
MGI:7386883

hm1

• Allelic Composition: Jmjd8^em1Kaso/Jmjd8^em1Kaso
• Genetic Background: C57BL/6-Jmjd8^em1Kaso

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating insulin level ( J:319518 )

• mice exhibit a dramatic reduction in both fasting and fed insulin levels

• mice fed a high fat diet (HFD) exhibit a dramatic reduction in serum insulin levels in both fed and fasting conditions

decreased circulating interleukin-1 beta level ( J:319518 )

• HFD-fed mice exhibit reduced serum level of IL-1b

improved glucose tolerance ( J:319518 )

• mice fed a HFD show improvement in glucose tolerance

• however, glucose tolerance is normal in mice fed a chow diet

• however, mice fed a HFD show no major changes in energy balance, locomotor activity, food intake, or body composition

increased insulin sensitivity ( J:319518 )

• mice exhibit increased insulin sensitivity on a chow diet

• mice fed a HFD show improvement in insulin sensitivity

• chow-fed mice show a lower Homeostatic Model Assessment (HOMA) of insulin resistance and mice fed a HFD exhibit improved HOMA of insulin resistance

adipose tissue

increased adipocyte glucose uptake ( J:319518 )

• adipocytes exhibit an approximate 2-fold increase in insulin-stimulated glucose uptake

abnormal white adipose tissue physiology ( J:319518 )

• macrophage infiltration in epididymal white adipose tissue (eWAT) of HFD-fed mice is reduced

• eWAT from HFD-fed mice shows increased expression of M2 markers and reduced expression of M1 markers, indicating a macrophage polarization toward M2

• adipocytes show attenuated LPS-mediated inflammatory gene stimulation

cellular

increased adipocyte glucose uptake ( J:319518 )

• adipocytes exhibit an approximate 2-fold increase in insulin-stimulated glucose uptake

immune system

decreased circulating interleukin-1 beta level ( J:319518 )

• HFD-fed mice exhibit reduced serum level of IL-1b

decreased inflammatory response ( J:319518 )

• macrophage infiltration in eWAT of HFD-fed mice is reduced

• adipocytes show attenuated LPS-mediated inflammatory gene stimulation

growth/size/body

growth/size/body region phenotype ( J:319518 )

N • mice exhibit normal body weight and body composition

N • mice fed a HFD show no major changes in body composition compared to controls