About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(CAG-Jmjd8)#Kaso
transgene insertion, Sona Kang
MGI:7386881
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Tg(Adipoq-cre)1Evdr/0
Tg(CAG-Jmjd8)#Kaso/0
involves: C57BL/6 * FVB/NJ MGI:7386885


Genotype
MGI:7386885
cn1
Allelic
Composition
Tg(Adipoq-cre)1Evdr/0
Tg(CAG-Jmjd8)#Kaso/0
Genetic
Background
involves: C57BL/6 * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Adipoq-cre)1Evdr mutation (3 available)
Tg(CAG-Jmjd8)#Kaso mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice fed a high fat diet (HFD) exhibit higher insulin levels
• mice fed a HFD exhibit worsened glucose tolerance
• however, mice fed a chow diet show no difference in glucose tolerance
• mice fed a HFD exhibit worsened insulin sensitivity
• however, mice fed a chow diet show no difference in the insulin tolerance test
• mice fed a HFD exhibit a higher Homeostatic Model Assessment (HOMA) of insulin resistance compared to control mice

adipose tissue
• HFD-fed mice show increased macrophage infiltration in epididymal white adipose tissue (eWAT)

immune system
• HFD-fed mice show increased macrophage infiltration in epididymal white adipose tissue (eWAT)

growth/size/body
N
• mice fed a chow diet show no differences in body weight, body composition, or tissue mass
• mice fed a high fat diet (HFD) show no changes in body weight or body composition or in energy homeostasis compared with controls





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory