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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(CAG-Jmjd8)#Kaso
transgene insertion, Sona Kang
MGI:7386881
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Tg(Adipoq-cre)1Evdr/0
Tg(CAG-Jmjd8)#Kaso/0
involves: C57BL/6 * FVB/NJ MGI:7386885


Genotype
MGI:7386885
cn1
Allelic
Composition
Tg(Adipoq-cre)1Evdr/0
Tg(CAG-Jmjd8)#Kaso/0
Genetic
Background
involves: C57BL/6 * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Adipoq-cre)1Evdr mutation (3 available)
Tg(CAG-Jmjd8)#Kaso mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice fed a high fat diet (HFD) exhibit higher insulin levels
• mice fed a HFD exhibit worsened glucose tolerance
• however, mice fed a chow diet show no difference in glucose tolerance
• mice fed a HFD exhibit worsened insulin sensitivity
• however, mice fed a chow diet show no difference in the insulin tolerance test
• mice fed a HFD exhibit a higher Homeostatic Model Assessment (HOMA) of insulin resistance compared to control mice

adipose tissue
• HFD-fed mice show increased macrophage infiltration in epididymal white adipose tissue (eWAT)

immune system
• HFD-fed mice show increased macrophage infiltration in epididymal white adipose tissue (eWAT)

growth/size/body
N
• mice fed a chow diet show no differences in body weight, body composition, or tissue mass
• mice fed a high fat diet (HFD) show no changes in body weight or body composition or in energy homeostasis compared with controls





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory