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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Crotem1Akw
endonuclease-mediated mutation 1, Elena Aikawa
MGI:7386925
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Crotem1Akw/Crotem1Akw C57BL/6J-Crotem1Akw MGI:7388204
cx2
 		Crotem1Akw/Crotem1Akw
Ldlrtm1Her/Ldlrtm1Her 		B6.Cg-Crotem1Akw Ldlrtm1Her MGI:7388201


Genotype
MGI:7388204
hm1
Allelic
Composition		 Crotem1Akw/Crotem1Akw
Genetic
Background		 C57BL/6J-Crotem1Akw
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crotem1Akw mutation (0 available); any Crot mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:331161 )
• mice exhibit normal gross anatomy including body weight, plasma total cholesterol, and triglyceride levels




Genotype
MGI:7388201
cx2
Allelic
Composition		 Crotem1Akw/Crotem1Akw
Ldlrtm1Her/Ldlrtm1Her
Genetic
Background		 B6.Cg-Crotem1Akw Ldlrtm1Her
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crotem1Akw mutation (0 available); any Crot mutation (46 available)
Ldlrtm1Her mutation (19 available); any Ldlr mutation (81 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal artery morphology ( J:331161 )
• mice fed a high-fat diet exhibit attenuated calcification of the aortic and carotid arteries compared with control mice
blood vessel inflammation ( J:331161 )
• reduced macrophage accumulation in mice fed a high-fat diet

immune system
blood vessel inflammation ( J:331161 )
• reduced macrophage accumulation in mice fed a high-fat diet

skeleton
skeleton phenotype ( J:331161 )
N
• mice exhibit normal bone density




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory