Phenotypes associated with this allele

• Allele Symbol: Ppp1r18^em1Mgin
• Allele Name: endonuclease-mediated mutation 1, Mark Ginsberg
• Allele ID: MGI:7388240
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ppp1r18^em1Mgin/Ppp1r18^em1Mgin	B6J.B6N-Ppp1r18^em1Mgin	MGI:7388245

Genotype
MGI:7388245

hm1

• Allelic Composition: Ppp1r18^em1Mgin/Ppp1r18^em1Mgin
• Genetic Background: B6J.B6N-Ppp1r18^em1Mgin

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:331428 )

N • mice exhibit normal lymph node size

impaired leukocyte migration ( J:331428 )

• slightly reduced CD4+ T cell homing to all peripheral lymphoid organs

decreased B cell number ( J:331428 )

• in the mesenteric lymph nodes, peripheral lymph nodes, and spleen

decreased T cell number ( J:331428 )

• in the mesenteric lymph nodes, peripheral lymph nodes, and spleen

increased leukocyte cell number ( J:331428 )

• twofold increase in white blood cells and lymphocyte in the peripheral blood

increased neutrophil cell number ( J:331428 )

• in the peripheral blood

small spleen ( J:331428 )

spleen hypoplasia ( J:331428 )

abnormal T cell physiology ( J:331428 )

• T cells exhibit reduced capacity to induce colitis

hematopoietic system

impaired leukocyte migration ( J:331428 )

• slightly reduced CD4+ T cell homing to all peripheral lymphoid organs

decreased B cell number ( J:331428 )

• in the mesenteric lymph nodes, peripheral lymph nodes, and spleen

decreased T cell number ( J:331428 )

• in the mesenteric lymph nodes, peripheral lymph nodes, and spleen

increased leukocyte cell number ( J:331428 )

• twofold increase in white blood cells and lymphocyte in the peripheral blood

increased neutrophil cell number ( J:331428 )

• in the peripheral blood

small spleen ( J:331428 )

spleen hypoplasia ( J:331428 )

abnormal T cell physiology ( J:331428 )

• T cells exhibit reduced capacity to induce colitis

cellular

impaired leukocyte migration ( J:331428 )

• slightly reduced CD4+ T cell homing to all peripheral lymphoid organs