Phenotypes associated with this allele

• Allele Symbol: Xpo7^{tm1d(KOMP)Wtsi}
• Allele Name: targeted mutation 1d, Wellcome Trust Sanger Institute
• Allele ID: MGI:7388255
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Xpo7^tm1d(KOMP)Wtsi/Xpo7^tm1d(KOMP)Wtsi	involves: C57BL/6N * FVB/N	MGI:7388424

Genotype
MGI:7388424

hm1

• Allelic Composition: Xpo7^{tm1d(KOMP)Wtsi}/Xpo7^{tm1d(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6N * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:331429 )

• after treatment with a single dose of 100 mg/kg/day PHZ to induce severe hematolytic anemia, mice exhibit impaired recovery and increased mortality compared with wild-type mice

embryonic lethality during organogenesis, incomplete penetrance ( J:331429 )

• some mice die between E11.5 and E13.5

hematopoietic system

hematopoietic system phenotype ( J:331429 )

N • mice exhibit normal spleen size and red blood cells

anemia ( J:331429 )

• mild

abnormal erythroid lineage cell morphology ( J:331429 )

• impaired terminal erythroid differentiation in PHZ-treated mice

abnormal stress erythropoiesis ( J:331429 )

• after treatment with a single dose of 100 mg/kg/day PHZ to induce severe hematolytic anemia, mice exhibit impaired recovery and increased mortality compared with wild-type mice

increased red blood cell distribution width ( J:331429 )

reticulocytosis ( J:331429 )

• in the bone marrow of PHZ-treated mice

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:331429 )

• after treatment with a single dose of 100 mg/kg/day PHZ to induce severe hematolytic anemia, mice exhibit impaired recovery and increased mortality compared with wild-type mice