Phenotypes associated with this allele

• Allele Symbol: Xpo7^em1.1Gmkf
• Allele Name: endonuclease-mediated mutation 1, Gary M Kupfer
• Allele ID: MGI:7388268
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Xpo7^em1.1Gmkf/Xpo7^em1.1Gmkf	involves: C57BL/6 * FVB/N	MGI:7388426

Genotype
MGI:7388426

hm1

• Allelic Composition: Xpo7^em1.1Gmkf/Xpo7^em1.1Gmkf
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:331429 )

• after treatment with a single dose of 100 mg/kg/day PHZ to induce severe hematolytic anemia, mice exhibit impaired recovery and died 3 days later unlike wild-type mice

hematopoietic system

hematopoietic system phenotype ( J:331429 )

N • mice exhibit normal spleen size

abnormal stress erythropoiesis ( J:331429 )

• after treatment with a single dose of 100 mg/kg/day PHZ to induce severe hematolytic anemia, mice exhibit impaired recovery and died 3 days later unlike wild-type mice

anemia ( J:331429 )

• mild

increased erythroid progenitor cell number ( J:331429 )

• in fetal liver

decreased erythrocyte cell number ( J:331429 )

decreased hematocrit ( J:331429 )

increased red blood cell distribution width ( J:331429 )

reticulocytosis ( J:331429 )

abnormal hematopoietic system physiology ( J:331429 )

• erythroid progenitor cells from the fetal liver exhibit reduced proliferation compared with wild-type cells

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:331429 )

• after treatment with a single dose of 100 mg/kg/day PHZ to induce severe hematolytic anemia, mice exhibit impaired recovery and died 3 days later unlike wild-type mice