Phenotypes associated with this allele

• Allele Symbol: Tmem45b^em1Tkwa
• Allele Name: endonuclease-mediated mutation 1, Tomoyuki Kawamata
• Allele ID: MGI:7388444
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tmem45b^em1Tkwa/Tmem45b^em1Tkwa	involves: C3H * C57BL/6N	MGI:7388459

Genotype
MGI:7388459

hm1

• Allelic Composition: Tmem45b^em1Tkwa/Tmem45b^em1Tkwa
• Genetic Background: involves: C3H * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal nociception after inflammation ( J:331496 )

• reduced long-lasting mechanical pain hypersensitivity in a CFA-induced inflammatory pain model or following surgical tissue incision

• however, mechanical hypersensitivity following spared nerve injury is normal

nervous system

abnormal neuron morphology ( J:331496 )

• decreased number of C-fiber-excitatory synaptic inputs in single substantia gelatinosa neurons of CFA-treated mice