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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mettl23em1Itwa
endonuclease-mediated mutation 1, Takeshi Iwata
MGI:7388493
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mettl23em1Itwa/Mettl23em1Itwa C57BL/6J-Mettl23em1Itwa/Itwa MGI:7388555
ht2
 		Mettl23em1Itwa/Mettl23+ C57BL/6J-Mettl23em1Itwa/Itwa MGI:7388554


Genotype
MGI:7388555
hm1
Allelic
Composition		 Mettl23em1Itwa/Mettl23em1Itwa
Genetic
Background		 C57BL/6J-Mettl23em1Itwa/Itwa
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mettl23em1Itwa mutation (0 available); any Mettl23 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
vision/eye phenotype ( J:330971 )
• mice exhibit normal intraocular pressure
retina ganglion cell degeneration ( J:330971 )
• significant at 6 months of age
optic nerve atrophy ( J:330971 )
• severe at 2 months of age
thin retina ganglion layer ( J:330971 )
• reduced ganglion cell complexes at 2 and 6 months of age with progressive axonal loss
abnormal rod electrophysiology ( J:330971 )
• reduced pSTR amplitudes of scotopic ERG at 6 months of age

nervous system
retina ganglion cell degeneration ( J:330971 )
• significant at 6 months of age
optic nerve atrophy ( J:330971 )
• severe at 2 months of age

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
glaucoma DOID:1686 J:330971




Genotype
MGI:7388554
ht2
Allelic
Composition		 Mettl23em1Itwa/Mettl23+
Genetic
Background		 C57BL/6J-Mettl23em1Itwa/Itwa
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mettl23em1Itwa mutation (0 available); any Mettl23 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
retina ganglion cell degeneration ( J:330971 )
• significant at 6 months of age
optic nerve atrophy ( J:330971 )
• severe at 2 months of age

vision/eye
vision/eye phenotype ( J:330971 )
N
• mice exhibit normal intraocular pressure
retina ganglion cell degeneration ( J:330971 )
• significant at 6 months of age
optic nerve atrophy ( J:330971 )
• severe at 2 months of age
thin retina ganglion layer ( J:330971 )
• reduced ganglion cell complexes at 2 and 6 months of age with progressive axonal loss
abnormal rod electrophysiology ( J:330971 )
• reduced pSTR amplitudes of scotopic ERG at 6 months of age

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
glaucoma DOID:1686 J:330971




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory