Phenotypes associated with this allele

• Allele Symbol: Adgrl4^tm1Adbg
• Allele Name: targeted mutation 1, Anna Dimberg
• Allele ID: MGI:7407284
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adgrl4^tm1Adbg/Adgrl4^tm1Adbg	involves: C57BL/6	MGI:7408066

Genotype
MGI:7408066

hm1

• Allelic Composition: Adgrl4^tm1Adbg/Adgrl4^tm1Adbg
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

neoplasm ( J:330927 )

N • mice exhibit normal tumor progression of orthotopic murine glioma

abnormal tumor vascularization ( J:330927 )

• GL261-bearing mice exhibit increased vessel perfusion within tumors with reduced vascular permeability and reduced tumor hypoxia compared with wild-type mice

• however, interaction between tumor blood vessels and pericytes is normal

cardiovascular system

cardiovascular system phenotype ( J:330927 )

N • mice exhibit normal angiogenesis and vascular development

abnormal tumor vascularization ( J:330927 )

• GL261-bearing mice exhibit increased vessel perfusion within tumors with reduced vascular permeability and reduced tumor hypoxia compared with wild-type mice

• however, interaction between tumor blood vessels and pericytes is normal