Phenotypes associated with this allele

• Allele Symbol: Elf4^em1Hdu
• Allele Name: endonuclease-mediated mutation 1, Hongqiang Du
• Allele ID: MGI:7408147
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Elf4^em1Hdu/Elf4^em1Hdu	C57BL/6-Elf4^em1Hdu	MGI:7408160

Genotype
MGI:7408160

hm1

• Allelic Composition: Elf4^em1Hdu/Elf4^em1Hdu
• Genetic Background: C57BL/6-Elf4^em1Hdu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal CD4-positive T cell differentiation ( J:328935 )

• naive CD4 T cells show increased Th17 polarization

abnormal macrophage physiology ( J:328935 )

• peritoneal macrophages and bone marrow-derived macrophages show decreased viral clearance of vesicular stomatitis virus (VSV) or herpes simplex virus type 1 (HSV-1) and macrophages produce increased type I interferons, IL-6, IL-1b, and TNF-alpha in response to viral infection

homeostasis/metabolism

abnormal interferon level ( J:328935 )

• macrophages produce increased type I interferons in response to viral infection with VSV or HSV-1

abnormal interleukin level ( J:328935 )

• macrophages produce increased IL-6 and IL-1b in response to viral infection with VSV or HSV-1

abnormal tumor necrosis factor level ( J:328935 )

• macrophages produce increased TNF-alpha in response to viral infection with VSV or HSV-1

immune system

abnormal CD4-positive T cell differentiation ( J:328935 )

• naive CD4 T cells show increased Th17 polarization

abnormal macrophage physiology ( J:328935 )

• peritoneal macrophages and bone marrow-derived macrophages show decreased viral clearance of vesicular stomatitis virus (VSV) or herpes simplex virus type 1 (HSV-1) and macrophages produce increased type I interferons, IL-6, IL-1b, and TNF-alpha in response to viral infection

abnormal interferon level ( J:328935 )

• macrophages produce increased type I interferons in response to viral infection with VSV or HSV-1

abnormal interleukin level ( J:328935 )

• macrophages produce increased IL-6 and IL-1b in response to viral infection with VSV or HSV-1

abnormal tumor necrosis factor level ( J:328935 )

• macrophages produce increased TNF-alpha in response to viral infection with VSV or HSV-1

increased susceptibility to viral infection ( J:328935 )

• peritoneal macrophages and bone marrow-derived macrophages show decreased viral clearance of vesicular stomatitis virus (VSV) or herpes simplex virus type 1 (HSV-1) and macrophages produce increased type I interferons, IL-6, IL-1b, and TNF-alpha in response to viral infection