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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rabep2em1Dmar
endonuclease-mediated mutation 1, Douglas Marchuk
MGI:7408531
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rabep2em1Dmar/Rabep2em1Dmar C57BL/6J-Rabep2em1Dmar MGI:7408544
ht2
 		Rabep2em1Dmar/Rabep2+ C57BL/6J-Rabep2em1Dmar MGI:7408545


Genotype
MGI:7408544
hm1
Allelic
Composition		 Rabep2em1Dmar/Rabep2em1Dmar
Genetic
Background		 C57BL/6J-Rabep2em1Dmar
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rabep2em1Dmar mutation (0 available); any Rabep2 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased cerebral infarct size ( J:330882 )
• with reduced collateral vessel connections following occlusion of the distal middle cerebral artery
• however, adenovirus expressing the endogenous or human gene rescues cerebral collateral vessel connections and infarct volume

nervous system
increased cerebral infarct size ( J:330882 )
• with reduced collateral vessel connections following occlusion of the distal middle cerebral artery
• however, adenovirus expressing the endogenous or human gene rescues cerebral collateral vessel connections and infarct volume




Genotype
MGI:7408545
ht2
Allelic
Composition		 Rabep2em1Dmar/Rabep2+
Genetic
Background		 C57BL/6J-Rabep2em1Dmar
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rabep2em1Dmar mutation (0 available); any Rabep2 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased cerebral infarct size ( J:330882 )
• with reduced collateral vessel connections following occlusion of the distal middle cerebral artery

nervous system
increased cerebral infarct size ( J:330882 )
• with reduced collateral vessel connections following occlusion of the distal middle cerebral artery




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory