Phenotypes associated with this allele

• Allele Symbol: Iqcn^em1Cya
• Allele Name: endonuclease-mediated mutation 1, Cyagen Biosciences
• Allele ID: MGI:7413046
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Iqcn^em1Cya/Iqcn^em1Cya	C57BL/6J-Iqcn^em1Cya	MGI:7413054

Genotype
MGI:7413054

hm1

• Allelic Composition: Iqcn^em1Cya/Iqcn^em1Cya
• Genetic Background: C57BL/6J-Iqcn^em1Cya

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:332231 )

♀N • female mice exhibit normal fertility

abnormal sperm head morphology ( J:332231 )

♂ • higher proportion of no sickle shape head than in wild-type mice

abnormal acrosome morphology ( J:332231 )

♂ • discontinuous and loosely anchored

♂ • however, mice exhibit normal percentage of sperm with spontaneous and induced acrosomal reaction

ectopic manchette ( J:332231 )

♂

elongated manchette ( J:332231 )

♂

male infertility ( J:332231 )

♂

decreased fertilization frequency ( J:332231 )

♂ • sperm exhibit total fertilization failure in vitro

♂ • however, fertilization could be rescued by intracytoplasmic sperm injection with assisted oocyte activation

abnormal sperm physiology ( J:332231 )

♂ • sperm fail to induce a calcium spike after being injected into wild-type eggs

cellular

abnormal sperm head morphology ( J:332231 )

♂ • higher proportion of no sickle shape head than in wild-type mice

abnormal acrosome morphology ( J:332231 )

♂ • discontinuous and loosely anchored

♂ • however, mice exhibit normal percentage of sperm with spontaneous and induced acrosomal reaction

ectopic manchette ( J:332231 )

♂

elongated manchette ( J:332231 )

♂