Phenotypes associated with this allele

• Allele Symbol: Rr338^em1Jeng
• Allele Name: endonuclease-mediated mutation 1, James Douglas Engel
• Allele ID: MGI:7413214
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rr338^em1Jeng/Rr338^em1Jeng	Not Specified	MGI:7413222

Genotype
MGI:7413222

hm1

• Allelic Composition: Rr338^em1Jeng/Rr338^em1Jeng
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal T cell differentiation ( J:232438 )

• reduced number of early T lineage progenitor (ETP)(Lin- cKit-hi CD25-) cells in thymus

abnormal T cell number ( J:232438 )

• reduced number of early T lineage progenitor (ETP)(Lin- cKit-hi CD25-) cells in thymus

• reduced number of CD4 SP T cells (CD4+ CD8- CD3+ TCRB+) in thymus, spleen and peripheral blood

• normal numbers of DN2, DN3, DN4, DP and CD8 SP T cells in thymus and CD8+ T cells in spleen and peripheral blood

decreased CD4-positive, alpha-beta T cell number ( J:232438 )

• reduced number of CD4 SP T cells (CD4+ CD8- CD3+ TCRB+) in thymus, spleen and peripheral blood

immune system

abnormal T cell differentiation ( J:232438 )

• reduced number of early T lineage progenitor (ETP)(Lin- cKit-hi CD25-) cells in thymus

abnormal T cell number ( J:232438 )

• reduced number of early T lineage progenitor (ETP)(Lin- cKit-hi CD25-) cells in thymus

• reduced number of CD4 SP T cells (CD4+ CD8- CD3+ TCRB+) in thymus, spleen and peripheral blood

• normal numbers of DN2, DN3, DN4, DP and CD8 SP T cells in thymus and CD8+ T cells in spleen and peripheral blood

decreased CD4-positive, alpha-beta T cell number ( J:232438 )

• reduced number of CD4 SP T cells (CD4+ CD8- CD3+ TCRB+) in thymus, spleen and peripheral blood