About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Wapltm1.2Kpfe
targeted mutation 1.2, Karl Pfeifer
MGI:7414361
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Wapltm1.2Kpfe/Wapltm1.2Kpfe involves: 129 * C57BL/6J * FVB/N MGI:7490367
ht2
 		Wapltm1.1Kpfe/Wapltm1.2Kpfe involves: 129 * C57BL/6J * FVB/N MGI:7490374
cx3
 		NipblGt(EUCE313f02)1.2Hmgu/Nipbl+
Wapltm1.2Kpfe/Wapl+ 		involves: 129 * C57BL/6J * FVB/N MGI:7444073
cx4
 		NipblGt(EUCE313f02)1.2Hmgu/Nipbl+
Wapltm1.1Kpfe/Wapltm1.2Kpfe 		involves: 129 * C57BL/6J * FVB/N MGI:7490411


Genotype
MGI:7490367
hm1
Allelic
Composition		 Wapltm1.2Kpfe/Wapltm1.2Kpfe
Genetic
Background		 involves: 129 * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wapltm1.2Kpfe mutation (0 available); any Wapl mutation (169 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality before implantation ( J:331699 )
• not recoverable at the blastocyst stage




Genotype
MGI:7490374
ht2
Allelic
Composition		 Wapltm1.1Kpfe/Wapltm1.2Kpfe
Genetic
Background		 involves: 129 * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wapltm1.1Kpfe mutation (1 available); any Wapl mutation (169 available)
Wapltm1.2Kpfe mutation (0 available); any Wapl mutation (169 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, complete penetrance ( J:331699 )
• found in expected numbers at E17.5 but absent at weaning




Genotype
MGI:7444073
cx3
Allelic
Composition		 NipblGt(EUCE313f02)1.2Hmgu/Nipbl+
Wapltm1.2Kpfe/Wapl+
Genetic
Background		 involves: 129 * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
NipblGt(EUCE313f02)1.2Hmgu mutation (0 available); any Nipbl mutation (124 available)
Wapltm1.2Kpfe mutation (0 available); any Wapl mutation (169 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal embryo size ( J:331699 )
• embryos are significantly larger than mutant mice wild-type for Wapl
• partial rescue of about 24% of reduced embryo growth phenotype

mortality/aging

growth/size/body
abnormal embryo size ( J:331699 )
• embryos are significantly larger than mutant mice wild-type for Wapl
• partial rescue of about 24% of reduced embryo growth phenotype




Genotype
MGI:7490411
cx4
Allelic
Composition		 NipblGt(EUCE313f02)1.2Hmgu/Nipbl+
Wapltm1.1Kpfe/Wapltm1.2Kpfe
Genetic
Background		 involves: 129 * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
NipblGt(EUCE313f02)1.2Hmgu mutation (0 available); any Nipbl mutation (124 available)
Wapltm1.1Kpfe mutation (1 available); any Wapl mutation (169 available)
Wapltm1.2Kpfe mutation (0 available); any Wapl mutation (169 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal embryo size ( J:331699 )
• embryos are significantly larger than mutant mice wild-type for Wapl
• partial rescue of about 24% of reduced embryo growth phenotype

mortality/aging

growth/size/body
abnormal embryo size ( J:331699 )
• embryos are significantly larger than mutant mice wild-type for Wapl
• partial rescue of about 24% of reduced embryo growth phenotype




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory