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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Wapltm1.2Kpfe
targeted mutation 1.2, Karl Pfeifer
MGI:7414361
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Wapltm1.2Kpfe/Wapltm1.2Kpfe involves: 129 * C57BL/6J * FVB/N MGI:7490367
ht2
 		Wapltm1.1Kpfe/Wapltm1.2Kpfe involves: 129 * C57BL/6J * FVB/N MGI:7490374
cx3
 		NipblGt(EUCE313f02)1.2Hmgu/Nipbl+
Wapltm1.2Kpfe/Wapl+ 		involves: 129 * C57BL/6J * FVB/N MGI:7444073
cx4
 		NipblGt(EUCE313f02)1.2Hmgu/Nipbl+
Wapltm1.1Kpfe/Wapltm1.2Kpfe 		involves: 129 * C57BL/6J * FVB/N MGI:7490411


Genotype
MGI:7490367
hm1
Allelic
Composition		 Wapltm1.2Kpfe/Wapltm1.2Kpfe
Genetic
Background		 involves: 129 * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wapltm1.2Kpfe mutation (0 available); any Wapl mutation (169 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality before implantation ( J:331699 )
• not recoverable at the blastocyst stage




Genotype
MGI:7490374
ht2
Allelic
Composition		 Wapltm1.1Kpfe/Wapltm1.2Kpfe
Genetic
Background		 involves: 129 * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wapltm1.1Kpfe mutation (1 available); any Wapl mutation (169 available)
Wapltm1.2Kpfe mutation (0 available); any Wapl mutation (169 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, complete penetrance ( J:331699 )
• found in expected numbers at E17.5 but absent at weaning




Genotype
MGI:7444073
cx3
Allelic
Composition		 NipblGt(EUCE313f02)1.2Hmgu/Nipbl+
Wapltm1.2Kpfe/Wapl+
Genetic
Background		 involves: 129 * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
NipblGt(EUCE313f02)1.2Hmgu mutation (0 available); any Nipbl mutation (124 available)
Wapltm1.2Kpfe mutation (0 available); any Wapl mutation (169 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal embryo size ( J:331699 )
• embryos are significantly larger than mutant mice wild-type for Wapl
• partial rescue of about 24% of reduced embryo growth phenotype

mortality/aging

growth/size/body
abnormal embryo size ( J:331699 )
• embryos are significantly larger than mutant mice wild-type for Wapl
• partial rescue of about 24% of reduced embryo growth phenotype




Genotype
MGI:7490411
cx4
Allelic
Composition		 NipblGt(EUCE313f02)1.2Hmgu/Nipbl+
Wapltm1.1Kpfe/Wapltm1.2Kpfe
Genetic
Background		 involves: 129 * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
NipblGt(EUCE313f02)1.2Hmgu mutation (0 available); any Nipbl mutation (124 available)
Wapltm1.1Kpfe mutation (1 available); any Wapl mutation (169 available)
Wapltm1.2Kpfe mutation (0 available); any Wapl mutation (169 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal embryo size ( J:331699 )
• embryos are significantly larger than mutant mice wild-type for Wapl
• partial rescue of about 24% of reduced embryo growth phenotype

mortality/aging

growth/size/body
abnormal embryo size ( J:331699 )
• embryos are significantly larger than mutant mice wild-type for Wapl
• partial rescue of about 24% of reduced embryo growth phenotype




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory