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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pold4em1Zzho
endonuclease-mediated mutation 1, Zhongcheng Zhou
MGI:7423649
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pold4em1Zzho/Pold4em1Zzho C57BL/6-Pold4em1Zzho MGI:7423672


Genotype
MGI:7423672
hm1
Allelic
Composition		 Pold4em1Zzho/Pold4em1Zzho
Genetic
Background		 C57BL/6-Pold4em1Zzho
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pold4em1Zzho mutation (0 available); any Pold4 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
extended life span ( J:331883 )
• mice exhibit an increased lifespan compared to wild-type mice
• mice are viable and fertile, show no increase in DNA damage, and appear to have normal DNA repair capacity

neoplasm
decreased liver tumor incidence ( J:331883 )
• mice exhibit decreased incidence of liver tumors, with no homozygotes showing liver tumors at 19-months-of age compared to 3 of 10 wild-type mice showing liver tumors at this time

liver/biliary system
decreased liver tumor incidence ( J:331883 )
• mice exhibit decreased incidence of liver tumors, with no homozygotes showing liver tumors at 19-months-of age compared to 3 of 10 wild-type mice showing liver tumors at this time




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory