Phenotypes associated with this allele

• Allele Symbol: Morc2a^tm1.1Pngr
• Allele Name: targeted mutation 1.1, Josef M Penninger
• Allele ID: MGI:7423695
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Morc2a^tm1.1Pngr/Morc2a^tm1.1Pngr Mphosph8^tm1c(EUCOMM)Wtsi/Mphosph8^tm1c(EUCOMM)Wtsi Tg(Nes-cre)1Kln/0	involves: 129P2/OlaHsd * C57BL/6N * SJL	MGI:7424798
cn2	Morc2a^tm1.1Pngr/Morc2a^tm1.1Pngr Tg(Nes-cre)1Kln/0	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:7424788

Genotype
MGI:7424798

cn1

• Allelic Composition: Morc2a^tm1.1Pngr/Morc2a^tm1.1Pngr; Mphosph8^{tm1c(EUCOMM)Wtsi}/Mphosph8^{tm1c(EUCOMM)Wtsi}; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:332344 )

• more so than in either single conditional knock-out mouse

nervous system

increased brain size ( J:332344 )

• increased brain to body ratio

abnormal corpora quadrigemina morphology ( J:332344 )

• exposed colliculi

craniofacial

domed cranium ( J:332344 )

growth/size/body

decreased body weight ( J:332344 )

skeleton

domed cranium ( J:332344 )

Genotype
MGI:7424788

cn2

• Allelic Composition: Morc2a^tm1.1Pngr/Morc2a^tm1.1Pngr; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

mortality/aging

premature death ( J:332344 )

nervous system

increased brain size ( J:332344 )

increased midbrain size ( J:332344 )

• dorsoventral and mediolateral expansion, predominantly of the collicular (tectal) and tegmental regions of the midbrain

abnormal corpora quadrigemina morphology ( J:332344 )

• exposed colliculi

abnormal neuron physiology ( J:332344 )

• increased neuronal activation throughout the cortex and reduced activation in the posterior brain

behavior/neurological

behavior/neurological phenotype ( J:332344 )

N • mice exhibit normal performance in a Y-maze, elevated plus maze, and Morris water maze

enhanced contextual conditioning behavior ( J:332344 )

• improved hippocampal-dependent fear-context memory

impaired coordination ( J:332344 )

• reduced motor performance and impaired motor function on a rotarod

• however, mice do not exhibit ataxia and have normal gaits

decreased grip strength ( J:332344 )

decreased locomotor activity ( J:332344 )

• in PhenoMaster cages and open field tests

craniofacial

domed cranium ( J:332344 )

• varying degrees of cranial alterations from normal to moderately domed

growth/size/body

decreased body size ( J:332344 )

decreased body weight ( J:332344 )

skeleton

domed cranium ( J:332344 )

• varying degrees of cranial alterations from normal to moderately domed