Phenotypes associated with this allele

• Allele Symbol: Eme1^{Tn(pb-Act-RFP)1.1Zhu}
• Allele Name: transposon insertion 1.1, Yuan Zhuang
• Allele ID: MGI:7424960
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Eme1^Tn(pb-Act-RFP)1.1Zhu/Eme1^Tn(pb-Act-RFP)1.1Zhu Gen1^Tn(pb-Act-RFP)1.1Zhu/Gen1^Tn(pb-Act-RFP)1.1Zhu	FVB/NJ-Eme1^Tn(pb-Act-RFP)1.1Zhu Gen1^Tn(pb-Act-RFP)1.1Zhu	MGI:7425028
cx2	Eme1^Tn(pb-Act-RFP)1.1Zhu/Eme1^Tn(pb-Act-RFP)1.1Zhu Gen1^Tn(pb-Act-RFP)1.1Zhu/Gen1^+	FVB/NJ-Eme1^Tn(pb-Act-RFP)1.1Zhu Gen1^Tn(pb-Act-RFP)1.1Zhu	MGI:7425029
cx3	Eme1^Tn(pb-Act-RFP)1.1Zhu/Eme1^+ Gen1^Tn(pb-Act-RFP)1.1Zhu/Gen1^Tn(pb-Act-RFP)1.1Zhu	FVB/NJ-Eme1^Tn(pb-Act-RFP)1.1Zhu Gen1^Tn(pb-Act-RFP)1.1Zhu	MGI:7425030
cx4	Eme1^Tn(pb-Act-RFP)1.1Zhu/Eme1^+ Gen1^Tn(pb-Act-RFP)1.1Zhu/Gen1^Tn(pb-Act-RFP)1.1Zhu	involves: C57BL/6J * FVB/NJ	MGI:7425031

Genotype
MGI:7425028

cx1

• Allelic Composition: Eme1^{Tn(pb-Act-RFP)1.1Zhu}/Eme1^{Tn(pb-Act-RFP)1.1Zhu}; Gen1^{Tn(pb-Act-RFP)1.1Zhu}/Gen1^{Tn(pb-Act-RFP)1.1Zhu}
• Genetic Background: FVB/NJ-Eme1^{Tn(pb-Act-RFP)1.1Zhu} Gen1^{Tn(pb-Act-RFP)1.1Zhu}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:330453 )

• no mice are present at E3.5

Genotype
MGI:7425029

cx2

• Allelic Composition: Eme1^{Tn(pb-Act-RFP)1.1Zhu}/Eme1^{Tn(pb-Act-RFP)1.1Zhu}; Gen1^{Tn(pb-Act-RFP)1.1Zhu}/Gen1⁺
• Genetic Background: FVB/NJ-Eme1^{Tn(pb-Act-RFP)1.1Zhu} Gen1^{Tn(pb-Act-RFP)1.1Zhu}

mortality/aging

prenatal lethality, complete penetrance ( J:330453 )

• no mice are born

Genotype
MGI:7425030

cx3

• Allelic Composition: Eme1^{Tn(pb-Act-RFP)1.1Zhu}/Eme1⁺; Gen1^{Tn(pb-Act-RFP)1.1Zhu}/Gen1^{Tn(pb-Act-RFP)1.1Zhu}
• Genetic Background: FVB/NJ-Eme1^{Tn(pb-Act-RFP)1.1Zhu} Gen1^{Tn(pb-Act-RFP)1.1Zhu}

cellular

increased cellular sensitivity to DNA damaging agents ( J:330453 )

• in mouse embryonic fibroblasts treated with camptothecin or etoposidecompared with cells from Eme1^{Tn(pb-Act-RFP)1.1Zhu} heterozygotes

• however, cells treated with mitomycin C, methyl methanesulfonate, or hydroxy- urea exhibit normal survival

Genotype
MGI:7425031

cx4

• Allelic Composition: Eme1^{Tn(pb-Act-RFP)1.1Zhu}/Eme1⁺; Gen1^{Tn(pb-Act-RFP)1.1Zhu}/Gen1^{Tn(pb-Act-RFP)1.1Zhu}
• Genetic Background: involves: C57BL/6J * FVB/NJ

cellular

abnormal cell physiology ( J:330453 )

reproductive system

reproductive system phenotype ( J:330453 )

N • mice exhibit normal testes and fertility