Analysis Tools|
Allele Symbol Allele Name Allele ID |
Cyc1em1(IMPC)Bay endonuclease-mediated mutation 1, Baylor College of Medicine MGI:7425624 |
||||||||||||
| Summary |
2 genotypes
|
|
|
Data Sources
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Cyc1em1(IMPC)Bay/Cyc1em1(IMPC)Bay mice exhibit embryonic lethality, with embryos recovered at E7.5 but not at E9.5. Embryos are smaller, show severe developmental delay, forming an epithelium with no obvious embryonic-extraembryonic boundary and abnormal epiblast.
|
• homozygous embryos are present at E7.5 (6% versus expected 25%, n=58), but not recovered at E9.5
|
|
• embryos show a severe developmental delay at E7.5
|
|
• embryos are much smaller than controls at E7.5
|
|
• a few Pou5f1/Oct4-positive cells are detected at E7.5
|
|
• embryos form an epithelium with no obvious embryonic or extraembryonic boundary
|
|
• embryos show a severe developmental delay at E7.5
|
|
• embryos are much smaller than controls at E7.5
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 11/12/2024 MGI 6.24 |
|
|
|
||
