Analysis Tools|
Allele Symbol Allele Name Allele ID |
Cyc1em1(IMPC)Bay endonuclease-mediated mutation 1, Baylor College of Medicine MGI:7425624 |
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| Summary |
2 genotypes
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Data Sources
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Cyc1em1(IMPC)Bay/Cyc1em1(IMPC)Bay mice exhibit embryonic lethality, with embryos recovered at E7.5 but not at E9.5. Embryos are smaller, show severe developmental delay, forming an epithelium with no obvious embryonic-extraembryonic boundary and abnormal epiblast.
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• homozygous embryos are present at E7.5 (6% versus expected 25%, n=58), but not recovered at E9.5
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• embryos show a severe developmental delay at E7.5
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• embryos are much smaller than controls at E7.5
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• a few Pou5f1/Oct4-positive cells are detected at E7.5
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• embryos form an epithelium with no obvious embryonic or extraembryonic boundary
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• embryos show a severe developmental delay at E7.5
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• embryos are much smaller than controls at E7.5
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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