All Phenotypes Fnip1<em1(IMPC)Ccpcz> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fnip1^{em1(IMPC)Ccpcz}
endonuclease-mediated mutation 1, Institute of Molecular Genetics
MGI:7425688

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fnip1^{em1(IMPC)Ccpcz}/Fnip1^{em1(IMPC)Ccpcz}	C57BL/6NCrl-Fnip1^{em1(IMPC)Ccpcz}/Ccpcz	MGI:7551112
ht2	Fnip1^{em1(IMPC)Ccpcz}/Fnip1⁺	C57BL/6NCrl-Fnip1^{em1(IMPC)Ccpcz}/Ccpcz	MGI:7628997

Allelic Composition	Fnip1^{em1(IMPC)Ccpcz}/Fnip1^{em1(IMPC)Ccpcz}
Genetic Background	C57BL/6NCrl-Fnip1^{em1(IMPC)Ccpcz}/Ccpcz

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fnip1^{em1(IMPC)Ccpcz} mutation (1 available); any Fnip1 mutation (60 available)

Data Sources

IMPC Data for Fnip1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased thigmotaxis ( J:211773 )

IMPC - CCP-IMG

decreased startle reflex ( J:211773 )

IMPC - CCP-IMG

decreased grip strength ( J:211773 )

IMPC - CCP-IMG

decreased locomotor activity ( J:211773 )

IMPC - CCP-IMG

cardiovascular system

dilated aorta ( J:211773 )

IMPC - CCP-IMG

abnormal heart morphology ( J:211773 )

IMPC - CCP-IMG

enlarged heart ( J:211773 )

IMPC - CCP-IMG

increased heart weight ( J:211773 )

IMPC - CCP-IMG

increased heart left ventricle size ( J:211773 )

IMPC - CCP-IMG

dilated heart left ventricle ( J:211773 )

IMPC - CCP-IMG

thick ventricular wall ( J:211773 )

IMPC - CCP-IMG

increased cardiac stroke volume ( J:211773 )

IMPC - CCP-IMG

increased cardiac muscle contractility ( J:211773 )

IMPC - CCP-IMG

decreased heart rate ( J:211773 )

IMPC - CCP-IMG

digestive/alimentary system

abnormal cecum morphology ( J:211773 )

IMPC - CCP-IMG

enlarged cecum ( J:211773 )

IMPC - CCP-IMG

endocrine/exocrine glands

abnormal thymus morphology ( J:211773 )

IMPC - CCP-IMG

enlarged thymus ( J:211773 )

IMPC - CCP-IMG

abnormal pancreas morphology ( J:211773 )

IMPC - CCP-IMG

growth/size/body

enlarged heart ( J:211773 )

IMPC - CCP-IMG

increased heart weight ( J:211773 )

IMPC - CCP-IMG

decreased body weight ( J:211773 )

IMPC - CCP-IMG

increased liver weight ( J:211773 )

IMPC - CCP-IMG

hematopoietic system

abnormal thymus morphology ( J:211773 )

IMPC - CCP-IMG

enlarged thymus ( J:211773 )

IMPC - CCP-IMG

decreased red blood cell distribution width ( J:211773 )

IMPC - CCP-IMG

increased neutrophil cell number ( J:211773 )

IMPC - CCP-IMG

decreased lymphocyte cell number ( J:211773 )

IMPC - CCP-IMG

abnormal spleen morphology ( J:211773 )

IMPC - CCP-IMG

small spleen ( J:211773 )

IMPC - CCP-IMG

decreased spleen weight ( J:211773 )

IMPC - CCP-IMG

homeostasis/metabolism

increased fasting circulating glucose level ( J:211773 )

IMPC - CCP-IMG

increased circulating iron level ( J:211773 )

IMPC - CCP-IMG

decreased respiratory quotient ( J:211773 )

IMPC - CCP-IMG

improved glucose tolerance ( J:211773 )

IMPC - CCP-IMG

immune system

abnormal thymus morphology ( J:211773 )

IMPC - CCP-IMG

enlarged thymus ( J:211773 )

IMPC - CCP-IMG

increased neutrophil cell number ( J:211773 )

IMPC - CCP-IMG

decreased lymphocyte cell number ( J:211773 )

IMPC - CCP-IMG

abnormal spleen morphology ( J:211773 )

IMPC - CCP-IMG

small spleen ( J:211773 )

IMPC - CCP-IMG

decreased spleen weight ( J:211773 )

IMPC - CCP-IMG

liver/biliary system

increased liver weight ( J:211773 )

IMPC - CCP-IMG

muscle

increased cardiac muscle contractility ( J:211773 )

IMPC - CCP-IMG

abnormal skeletal muscle morphology ( J:211773 )

IMPC - CCP-IMG

respiratory system

decreased lung elastance ( J:211773 )

IMPC - CCP-IMG

decreased lung tissue damping ( J:211773 )

IMPC - CCP-IMG

abnormal inspiratory capacity ( J:211773 )

IMPC - CCP-IMG

decreased airway resistance ( J:211773 )

IMPC - CCP-IMG

increased lung compliance ( J:211773 )

IMPC - CCP-IMG

skeleton

abnormal spine curvature ( J:211773 )

IMPC - CCP-IMG

Allelic Composition	Fnip1^{em1(IMPC)Ccpcz}/Fnip1⁺
Genetic Background	C57BL/6NCrl-Fnip1^{em1(IMPC)Ccpcz}/Ccpcz

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fnip1^{em1(IMPC)Ccpcz} mutation (1 available); any Fnip1 mutation (60 available)

Data Sources

IMPC Data for Fnip1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased freezing behavior ( J:211773 )

IMPC - CCP-IMG

cardiovascular system

thick ventricular wall ( J:211773 )

IMPC - CCP-IMG

endocrine/exocrine glands

abnormal thymus morphology ( J:211773 )

IMPC - CCP-IMG

small thymus ( J:211773 )

IMPC - CCP-IMG

abnormal mammary gland morphology ( J:211773 )

IMPC - CCP-IMG

hematopoietic system

abnormal thymus morphology ( J:211773 )

IMPC - CCP-IMG

small thymus ( J:211773 )

IMPC - CCP-IMG

homeostasis/metabolism

increased fasting circulating glucose level ( J:211773 )

IMPC - CCP-IMG

immune system

abnormal thymus morphology ( J:211773 )

IMPC - CCP-IMG

small thymus ( J:211773 )

IMPC - CCP-IMG

integument

abnormal mammary gland morphology ( J:211773 )

IMPC - CCP-IMG

respiratory system

decreased lung elastance ( J:211773 )

IMPC - CCP-IMG

decreased lung tissue damping ( J:211773 )

IMPC - CCP-IMG

abnormal inspiratory capacity ( J:211773 )

IMPC - CCP-IMG

increased lung compliance ( J:211773 )

IMPC - CCP-IMG

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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