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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ndufa11em1(IMPC)Bay
endonuclease-mediated mutation 1, Baylor College of Medicine
MGI:7425854
Summary 2 genotypes


Genotype
MGI:7720071
hm1
Allelic
Composition		 Ndufa11em1(IMPC)Bay/Ndufa11em1(IMPC)Bay
Genetic
Background		 C57BL/6NJ-Ndufa11em1(IMPC)Bay/Mmmh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndufa11em1(IMPC)Bay mutation (1 available); any Ndufa11 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Ndufa11em1(IMPC)Bay/Ndufa11em1(IMPC)Bay mice exhibit embryonic lethality, with embryos recovered at E7.5 but not at E9.5. Embryos are smaller and form a rudimentary egg cylinder but no primitive streak or hallmarks of gastrulation are seen at E7.5.

mortality/aging
embryonic lethality between implantation and placentation, complete penetrance ( J:279207 )
• homozygous embryos are present in expected Mendelian ratios at E7.5; no homozygous embryos are recovered at E9.5

embryo
failure to gastrulate ( J:279207 )
• no morphological hallmarks typical of gastrulating embryos are observed at E7.5
decreased embryo size ( J:279207 )
• embryos are much smaller than controls at E7.5
abnormal egg cylinder morphology ( J:279207 )
• a rudimentary egg cylinder is observed at E7.5
absent head fold ( J:279207 )
• no head folds are present at E7.5
absent primitive node ( J:279207 )
• no embryonic node is present at E7.5
failure of primitive streak formation ( J:279207 )
• no morphological evidence of primitive streak formation is observed at E7.5

growth/size/body
decreased embryo size ( J:279207 )
• embryos are much smaller than controls at E7.5




Genotype
MGI:7472120
hm2
Allelic
Composition		 Ndufa11em1(IMPC)Bay/Ndufa11em1(IMPC)Bay
Genetic
Background		 C57BL/6N-Ndufa11em1(IMPC)Bay/BayMmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndufa11em1(IMPC)Bay mutation (1 available); any Ndufa11 mutation (17 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory