About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ndufa11em1(IMPC)Bay
endonuclease-mediated mutation 1, Baylor College of Medicine
MGI:7425854
Summary 2 genotypes


Genotype
MGI:7720071
hm1
Allelic
Composition		 Ndufa11em1(IMPC)Bay/Ndufa11em1(IMPC)Bay
Genetic
Background		 C57BL/6NJ-Ndufa11em1(IMPC)Bay/Mmmh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndufa11em1(IMPC)Bay mutation (1 available); any Ndufa11 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Ndufa11em1(IMPC)Bay/Ndufa11em1(IMPC)Bay mice exhibit embryonic lethality, with embryos recovered at E7.5 but not at E9.5. Embryos are smaller and form a rudimentary egg cylinder but no primitive streak or hallmarks of gastrulation are seen at E7.5.

mortality/aging
embryonic lethality between implantation and placentation, complete penetrance ( J:279207 )
• homozygous embryos are present in expected Mendelian ratios at E7.5; no homozygous embryos are recovered at E9.5

embryo
failure to gastrulate ( J:279207 )
• no morphological hallmarks typical of gastrulating embryos are observed at E7.5
decreased embryo size ( J:279207 )
• embryos are much smaller than controls at E7.5
decreased egg cylinder size ( J:279207 )
• a rudimentary egg cylinder is observed at E7.5
absent head fold ( J:279207 )
• no head folds are present at E7.5
absent primitive node ( J:279207 )
• no embryonic node is present at E7.5
failure of primitive streak formation ( J:279207 )
• no morphological evidence of primitive streak formation is observed at E7.5

growth/size/body
decreased embryo size ( J:279207 )
• embryos are much smaller than controls at E7.5




Genotype
MGI:7472120
hm2
Allelic
Composition		 Ndufa11em1(IMPC)Bay/Ndufa11em1(IMPC)Bay
Genetic
Background		 C57BL/6N-Ndufa11em1(IMPC)Bay/BayMmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndufa11em1(IMPC)Bay mutation (1 available); any Ndufa11 mutation (17 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory