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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sart3em1(IMPC)Bay
endonuclease-mediated mutation 1, Baylor College of Medicine
MGI:7425960
Summary 3 genotypes


Genotype
MGI:7720055
hm1
Allelic
Composition		 Sart3em1(IMPC)Bay/Sart3em1(IMPC)Bay
Genetic
Background		 C57BL/6NJ-Sart3em1(IMPC)Bay/Mmmh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sart3em1(IMPC)Bay mutation (1 available); any Sart3 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Sart3em1(IMPC)Bay/Sart3em1(IMPC)Bay mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. Blastocysts hatch from the zona pellucida but form irregular outgrowths.

mortality/aging
embryonic lethality between implantation and somite formation, complete penetrance ( J:279207 )
• early blastocysts are present at E3.5 (17% versus expected 25%, n=18); no homozygous embryos are recovered at E7.5
• however, excess resorption sites suggest that embryos elicit a decidual response in vivo

reproductive system
abnormal embryo implantation ( J:279207 )
• in vitro, blastocysts hatch from the zona pellucida but form irregular outgrowths after 3 days in culture




Genotype
MGI:7472220
hm2
Allelic
Composition		 Sart3em1(IMPC)Bay/Sart3em1(IMPC)Bay
Genetic
Background		 C57BL/6N-Sart3em1(IMPC)Bay/BayMmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sart3em1(IMPC)Bay mutation (1 available); any Sart3 mutation (46 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:7472219
ht3
Allelic
Composition		 Sart3em1(IMPC)Bay/Sart3+
Genetic
Background		 C57BL/6N-Sart3em1(IMPC)Bay/BayMmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sart3em1(IMPC)Bay mutation (1 available); any Sart3 mutation (46 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo

growth/size/body
embryonic growth retardation ( J:211773 )
IMPC - BCM
abnormal embryo size ( J:211773 )
IMPC - BCM




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory