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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Afg2bem1(IMPC)Bay
endonuclease-mediated mutation 1, Baylor College of Medicine
MGI:7426002
Summary 3 genotypes


Genotype
MGI:7551033
hm1
Allelic
Composition
Afg2bem1(IMPC)Bay/Afg2bem1(IMPC)Bay
Genetic
Background
C57BL/6N-Afg2bem1(IMPC)Bay/BayMmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Afg2bem1(IMPC)Bay mutation (1 available); any Afg2b mutation (4 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:7735130
hm2
Allelic
Composition
Afg2bem1(IMPC)Bay/Afg2bem1(IMPC)Bay
Genetic
Background
C57BL/6NJ-Afg2bem1(IMPC)Bay/Mmmh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Afg2bem1(IMPC)Bay mutation (1 available); any Afg2b mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Afg2bem1(IMPC)Bay/Afg2bem1(IMPC)Bay mice exhibit embryonic lethality, with embryos recovered at E3.5 as early blastocysts but not at E7.5. Blastocysts fail to hatch from the zona pellucida and die after 3 days in culture.

mortality/aging
• although early blastocysts are present in expected ratios at E3.5, no homozygous embryos are recovered at E7.5
• however, excess resorption sites suggest that embryos elicit a decidual response in vivo

embryo
• in vitro, blastocysts fail to hatch from the zona pellucida and are dead after 3 days in culture




Genotype
MGI:7628905
ht3
Allelic
Composition
Afg2bem1(IMPC)Bay/Afg2b+
Genetic
Background
C57BL/6N-Afg2bem1(IMPC)Bay/BayMmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Afg2bem1(IMPC)Bay mutation (1 available); any Afg2b mutation (4 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory